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Home Antibody All anti-POMC antibodies

Anti-POMC TRUEMAB Antibody Clone OTI1A8

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA506608
  • POMC mouse monoclonal antibody, clone OTI1A8 (formerly 1A8)
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC422129) , 20ug Explanation
100ul $325 In Stock
CF506608
  • Carrier-free (BSA/glycerol-free) POMC mouse monoclonal antibody, clone OTI1A8 (formerly 1A8)
100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenFull length human recombinant protein of human POMC(NP_001030333) produced in HEK293T cell.
Clone NameClone OTI1A8 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC, IF Suggested Dilutions WB 1:4000, IF 1:100,
Predicted MW Explanation 26.6 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens proopiomelanocortin (POMC), transcript variant 1
Alternative NameACTH; CLIP; LPH; MSH; NPP; POC
Database LinkNP_001030333
Entrez Gene 5443 Human
FunctionThis gene encodes a polypeptide hormone precursor that undergoes extensive, tissue-specific, post-translational processing via cleavage by subtilisin-like enzymes known as prohormone convertases. There are eight potential cleavage sites within the polypeptide precursor and, depending on tissue type and the available convertases, processing may yield as many as ten biologically active peptides involved in diverse cellular functions. The encoded protein is synthesized mainly in corticotroph cells of the anterior pituitary where four cleavage sites are used; adrenocorticotrophin, essential for normal steroidogenesis and the maintenance of normal adrenal weight, and lipotropin beta are the major end products. In other tissues, including the hypothalamus, placenta, and epithelium, all cleavage sites may be used, giving rise to peptides with roles in pain and energy homeostasis, melanocyte stimulation, and immune modulation. These include several distinct melanotropins, lipotropins, and endorphins that are contained within the adrenocorticotrophin and beta-lipotropin peptides. Mutations in this gene have been associated with early onset obesity, adrenal insufficiency, and red hair pigmentation. Alternatively spliced transcript variants encoding the same protein have been described. [provided by RefSeq, Jul 2008].
Related PathwayDruggable Genome MelanogenesisAdipocytokine signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY POMC (RC215351, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-POMC.
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Immunohistochemical staining of paraffin-embedded Human pancreas tissue within the normal limits using anti-POMC mouse monoclonal antibody. (TA506608)
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Immunofluorescent staining of HeLa cells using anti-POMC mouse monoclonal antibody (TA506608).
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