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Home Antibody All anti-MDM4 antibodies

Anti-MDM4 TRUEMAB Antibody Clone OTI4E10

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA505712 MDM4 (MDMX) mouse monoclonal antibody, clone OTI4E10 (formerly 4E10) 100ul $325 In Stock
LC400856 MDM4 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF505712 Carrier-free (BSA/glycerol-free) MDM4 mouse monoclonal antibody, clone OTI4E10 (formerly 4E10) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type

Buy any antibody of 100ul or more, get a free package of 3 loading control antibody samples. View Details Add to Shopping Cart

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WB(1)
IF(1)

OriGene Data

ImmunogenFull length human recombinant protein of human MDM4(NP_002384) produced in HEK293T cell.
Clone NameClone OTI4E10 IsotypeIgG1
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IF Suggested Dilutions WB 1:2000, IF 1:100,
Predicted MW Explanation 54.7 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens MDM4, p53 regulator (MDM4), transcript variant 1
Alternative NameHDMX; MDMX; MRP1
Database LinkNP_002384
Entrez Gene 4194 Human
FunctionThis gene encodes a nuclear protein that contains a p53 binding domain at the N-terminus and a RING finger domain at the C-terminus, and shows structural similarity to p53-binding protein MDM2. Both proteins bind the p53 tumor suppressor protein and inhibit its activity, and have been shown to be overexpressed in a variety of human cancers. However, unlike MDM2 which degrades p53, this protein inhibits p53 by binding its transcriptional activation domain. This protein also interacts with MDM2 protein via the RING finger domain, and inhibits the latter's degradation. So this protein can reverse MDM2-targeted degradation of p53, while maintaining suppression of p53 transactivation and apoptotic functions. Alternatively spliced transcript variants encoding different isoforms have been noted for this gene. [provided by RefSeq, Feb 2011].
Related PathwayTranscription FactorsDruggable Genome p53 signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MDM4 (RC209620, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MDM4.
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Anti-MDM4 mouse monoclonal antibody (TA505712) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MDM4(RC209620).
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