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Home Antibody All anti-RTKN antibodies

Anti-RTKN TRUEMAB Antibody Clone OTI1A4

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA505051 RTKN mouse monoclonal antibody, clone OTI1A4 (formerly 1A4) 100ul $325 In Stock
LC403228 RTKN HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF505051 Carrier-free (BSA/glycerol-free) RTKN mouse monoclonal antibody, clone OTI1A4 (formerly 1A4) 100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(1)
IHC(4)
IF(1)

OriGene Data

ImmunogenFull length human recombinant protein of human RTKN(NP_149035) produced in HEK293T cell.
Clone NameClone OTI1A4 IsotypeIgG2a
Species ReactivityHuman Concentration1 mg/ml
Guaranteed Application *WB, IHC, IF Suggested Dilutions WB 1:2000, IHC 1:150, IF 1:100,
Predicted MW Explanation 61 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens rhotekin (RTKN), transcript variant 2
Alternative NameB5
Database LinkNP_149035
Entrez Gene 6242 Human
FunctionThis gene encodes a scaffold protein that interacts with GTP-bound Rho proteins. Binding of this protein inhibits the GTPase activity of Rho proteins. This protein may interfere with the conversion of active, GTP-bound Rho to the inactive GDP-bound form by RhoGAP. Rho proteins regulate many important cellular processes, including cytokinesis, transcription, smooth muscle contraction, cell growth and transformation. Dysregulation of the Rho signal transduction pathway has been implicated in many forms of cancer. Alternative splicing results in multiple transcript variants encoding different isoforms. [provided by RefSeq].
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY RTKN (RC204517, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-RTKN.
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Immunohistochemical staining of paraffin-embedded Human breast tissue within the normal limits using anti-RTKN mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505051)
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Immunohistochemical staining of paraffin-embedded Human Kidney tissue within the normal limits using anti-RTKN mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505051)
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Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-RTKN mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505051)
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Immunohistochemical staining of paraffin-embedded Human endometrium tissue within the normal limits using anti-RTKN mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA505051)
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Anti-RTKN mouse monoclonal antibody (TA505051) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY RTKN(RC204517).
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