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Anti-FOLH1 TRUEMAB Antibody Clone OTI3H5
TrueMAB Antibodies - Made against Authentic Protein Antigens
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Also for FOLH1 (NM_004476)
|Full length human recombinant protein of human FOLH1(NP_004467) produced in HEK293T cell.|
|WB, IHC, IF, FC
||WB 1:500~1000, IHC 1:150, IF 1:100, FLOW 1:100,
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens folate hydrolase (prostate-specific membrane antigen) 1 (FOLH1), transcript variant 1|
|FGCP; FOLH; GCP2; GCPII; mGCP; NAALAD1; NAALAdase; PSM; PSMA|
Entrez Gene 2346 Human
Entrez Gene 53320 Mouse
|This gene encodes a type II transmembrane glycoprotein belonging to the M28 peptidase family. The protein acts as a glutamate carboxypeptidase on different alternative substrates, including the nutrient folate and the neuropeptide N-acetyl-l-aspartyl-l-glutamate and is expressed in a number of tissues such as prostate, central and peripheral nervous system and kidney. A mutation in this gene may be associated with impaired intestinal absorption of dietary folates, resulting in low blood folate levels and consequent hyperhomocysteinemia. Expression of this protein in the brain may be involved in a number of pathological conditions associated with glutamate excitotoxicity. In the prostate the protein is up-regulated in cancerous cells and is used as an effective diagnostic and prognostic indicator of prostate cancer. This gene likely arose from a duplication event of a nearby chromosomal region. Alternative splicing gives rise to multiple transcript variants encoding several different isoforms. [provided by RefSeq].|
|TransmembraneProteaseDruggable Genome |
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FOLH1 (RC218310, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FOLH1.
Western blot analysis of extracts (35ug) from 9 different cell lines by usin g anti-FOLH1 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-FOLH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504752)
Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-FOLH1 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA504752)
Anti-FOLH1 mouse monoclonal antibody (TA504752) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY FOLH1(RC218310).
HEK293T cells transfected with either RC218310 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-FOLH1 antibody(TA504752), and then analyzed by flow cytometry.