Anti-FMR1 Antibody, clone 2C3

Also for FMR1 (NM_002024)

OriGene Data

Immunogen	Human recombinant protein fragment corresponding to amino acids 26-279 of human FMR1(NP_002015) produced in HEK293T cell.
Clone Name	clone 2C3	Isotype	IgG2a
Species Reactivity	Human , Dog , Rat , Monkey , Mouse	Concentration	0.5~1.0 mg/ml (Lot Dependent)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB 1:200~1000, IHC 1:150,
Buffer	PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification	Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)

Reference Data

Target Name	Homo sapiens fragile X mental retardation 1 (FMR1), transcript variant ISO1
Alternative Name	FMRP; FRAXA; POF; POF1; POFX
Database Link	NP_002015
Function	The protein encoded by this gene binds RNA and is associated with polysomes. The encoded protein may be involved in mRNA trafficking from the nucleus to the cytoplasm. A trinucleotide repeat (CGG) in the 5' UTR is normally found at 6-53 copies, but an expansion to 55-230 repeats is the cause of fragile X syndrome. Expansion of the trinucleotide repeat may also cause one form of premature ovarian failure (POF1). Multiple alternatively spliced transcript variants that encode different protein isoforms and which are located in different cellular locations have been described for this gene. [provided by RefSeq, May 2010].
Related Pathway

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WB Image

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FMR1 (RC222699, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FMR1.

WB Image

Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-FMR1 monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).

IHC Image

Immunohistochemical staining of paraffin-embedded Human breast tissue using anti-FMR1 mouse monoclonal antibody. (TA504293)

IHC Image

Immunohistochemical staining of paraffin-embedded Human Kidney tissue using anti-FMR1 mouse monoclonal antibody. (TA504293)

IHC Image

Immunohistochemical staining of paraffin-embedded Carcinoma of Human liver tissue using anti-FMR1 mouse monoclonal antibody. (TA504293)

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human ovary tissue using anti-FMR1 mouse monoclonal antibody. (TA504293)

IHC Image

Immunohistochemical staining of paraffin-embedded Human pancreas tissue using anti-FMR1 mouse monoclonal antibody. (TA504293)

IHC Image

Immunohistochemical staining of paraffin-embedded Carcinoma of Human pancreas tissue using anti-FMR1 mouse monoclonal antibody. (TA504293)

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of Human endometrium tissue using anti-FMR1 mouse monoclonal antibody. (TA504293)

IHC Image

Immunohistochemical staining of paraffin-embedded Carcinoma of Human prostate tissue using anti-FMR1 mouse monoclonal antibody. (TA504293)

IHC Image

Immunohistochemical staining of paraffin-embedded Carcinoma of Human bladder tissue using anti-FMR1 mouse monoclonal antibody. (TA504293)

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Anti-FMR1 TrueMAB Antibody clone 2C3

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

OriGene Data

Reference Data