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Anti-MVK TRUEMAB Antibody clone 1D7
TrueMAB Antibodies - Made against Authentic Protein Antigens
|Full length human recombinant protein of human MVK (NP_000422) produced in HEK293T cell. |
|| WB 1:2000, IF 1:100,
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens mevalonate kinase (MVK), transcript variant 1|
|LRBP; MK; MVLK; POROK3|
Entrez Gene 4598 Human
|This gene encodes the peroxisomal enzyme mevalonate kinase. Mevalonate is a key intermediate, and mevalonate kinase a key early enzyme, in isoprenoid and sterol synthesis. Mevalonate kinase deficiency caused by mutation of this gene results in mevalonic aciduria, a disease characterized psychomotor retardation, failure to thrive, hepatosplenomegaly, anemia and recurrent febrile crises. Defects in this gene also cause hyperimmunoglobulinaemia D and periodic fever syndrome, a disorder characterized by recurrent episodes of fever associated with lymphadenopathy, arthralgia, gastrointestinal dismay and skin rash. Two transcript variants that encode the same protein have been found for this gene. [provided by RefSeq, Jul 2008]. |
|Druggable Genome Terpenoid backbone biosynthesisMetabolic pathways|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY MVK (RC201971, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-MVK.
Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-MVK monoclonal antibody (HepG2: human; HeLa: human; SVT2: mouse; A549: human; COS7: monkey; Jurkat: human; MDCK: canine; PC12: rat; MCF7: human).
Anti-MVK mouse monoclonal antibody (TA502934) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY MVK(RC201971).