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Home Antibody All anti-BTRC antibodies

Anti-BTRC TRUEMAB Antibody clone 1F10

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA502463
  • BTRC (Beta TRCP) mouse monoclonal antibody, clone 1F10
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403255) , 20ug Explanation
100ul 325 In Stock
CF502463
  • Carrier-free (BSA/glycerol-free) BTRC mouse monoclonal antibody,clone 1F10
100ug $450 3-4 weeks
This antibody qualifies for Season of Giving promotion: Earn $50 Amazon gift card (use promo code SPQ12081) or donation to Cancer.org (promo code SPQ12082) with $600 purchase of UltraMAB or TrueMAB. Click for details
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WB(1)
FC(1)

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 52-354 of human BTRC(NP_378663) produced in HEK293T cell.
Clone Nameclone 1F10 IsotypeIgG1
Species ReactivityHuman Concentration0.72 mg/ml
Guaranteed Application *WB, FC Suggested Dilutions WB 1:2000, FLOW 1:100,
Predicted MW Explanation 68.7 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens beta-transducin repeat containing E3 ubiquitin protein ligase (BTRC), transcript variant 1
Alternative NameBETA-TRCP; betaTrCP; bTrCP; bTrCP1; FBW1A; FBXW1; FBXW1A; FWD1
Database LinkNP_378663
Entrez Gene 8945 Human
FunctionThis gene encodes a member of the F-box protein family which is characterized by an approximately 40 amino acid motif, the F-box. The F-box proteins constitute one of the four subunits of ubiquitin protein ligase complex called SCFs (SKP1-cullin-F-box), which function in phosphorylation-dependent ubiquitination. The F-box proteins are divided into 3 classes: Fbws containing WD-40 domains, Fbls containing leucine-rich repeats, and Fbxs containing either different protein-protein interaction modules or no recognizable motifs. The protein encoded by this gene belongs to the Fbws class; in addition to an F-box, this protein contains multiple WD-40 repeats. The encoded protein mediates degradation of CD4 via its interaction with HIV-1 Vpu. It has also been shown to ubiquitinate phosphorylated NFKBIA (nuclear factor of kappa light polypeptide gene enhancer in B-cells inhibitor, alpha), targeting it for degradation and thus activating nuclear factor kappa-B. Alternatively spliced transcript variants have been described. A related pseudogene exists in chromosome 6. [provided by RefSeq, Mar
Related PathwayDruggable Genome Oocyte meiosisUbiquitin mediated proteolysisWnt signaling pathwayHedgehog signaling pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY BTRC (RC207025, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-BTRC.
FC Image
HEK293T cells transfected with either RC207025 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-BTRC antibody(TA502463), and then analyzed by flow cytometry.

 

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