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Anti-FADD TRUEMAB Antibody Clone OTI1C11

TrueMAB™ Antibodies - Made against Authentic Protein Antigens


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA501434 anti-FADD mouse monoclonal antibody, clone OTI1C11 (formerly 1C11) 100ul 379
In Stock
LC401265 FADD HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF501434 Carrier-free (BSA/glycerol-free) FADD mouse monoclonal antibody, clone OTI1C11 (formerly 1C11) 100ug $450 3-4 weeks
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OriGene Data

ImmunogenFull length human recombinant protein of human FADD (NP_003815) produced in HEK293T cell.
Clone NameClone OTI1C11 IsotypeIgG1
Species ReactivityHuman Concentration0.63 mg/ml
Guaranteed Application *WB, FC Suggested DilutionsWB 1:2000, FLOW 1:100
Predicted MW Explanation 23.1 kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens Fas (TNFRSF6)-associated via death domain (FADD)
Alternative NameGIG3; MORT1
Database LinkNP_003815
Entrez Gene 8772 Human
FunctionThe protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq].
Related PathwayDruggable Genome ApoptosisToll-like receptor signaling pathwayRIG-I-like receptor signaling pathwayAlzheimer's diseasePathways in cancer

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FADD (RC201805, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FADD.

WB Image
Western blot analysis of extracts (10ug) from 5 different cell lines by using anti-FADD monoclonal antibody at 1:200 dilution.

FC Image
HEK293T cells transfected with either RC201805 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-FADD antibody(TA501434), and then analyzed by flow cytometry.


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