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Anti-FADD TrueMAB Antibody clone 1C11
TrueMAB Antibodies - Made against Authentic Protein Antigens
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Also for FADD (NM_003824)
|Full length human recombinant protein of human FADD (NP_003815) produced in HEK293T cell.|
||0.5~1.0 mg/ml (Lot Dependent)
||WB 1:2000, FLOW 1:100
|PBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)
|Homo sapiens Fas (TNFRSF6)-associated via death domain (FADD)|
|The protein encoded by this gene is an adaptor molecule that interacts with various cell surface receptors and mediates cell apoptotic signals. Through its C-terminal death domain, this protein can be recruited by TNFRSF6/Fas-receptor, tumor necrosis factor receptor, TNFRSF25, and TNFSF10/TRAIL-receptor, and thus it participates in the death signaling initiated by these receptors. Interaction of this protein with the receptors unmasks the N-terminal effector domain of this protein, which allows it to recruit caspase-8, and thereby activate the cysteine protease cascade. Knockout studies in mice also suggest the importance of this protein in early T cell development. [provided by RefSeq].|
Toll-like receptor signaling pathway
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY FADD (RC201805, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-FADD.
HEK293T cells transfected with either RC201805 overexpress plasmid(Red) or empty vector control plasmid(Blue) were immunostained by anti-FADD antibody(TA501434), and then analyzed by flow cytometry.