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Home Antibody All anti-CYP1A2 antibodies

Anti-CYP1A2 TRUEMAB Antibody Clone OTI1E12

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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SKU Description Amount Price Availability*  
TA501172 anti-CYP1A2 (Cytochrome P450 1A2) mouse monoclonal antibody, clone OTI1E12 (formerly 1E12) 100ul $325 In Stock
LC424529 CYP1A2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF501172 Carrier-free (BSA/glycerol-free) CYP1A2 mouse monoclonal antibody, clone OTI1E12 (formerly 1E12) 100ug $450 3-4 weeks
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WB(1)
IHC(2)
IF(1)
FC(1)
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Also for CYP1A2 (NM_000761)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenFull length human recombinant protein of human CYP1A2 (NP_000752) produced in HEK293T cell.
Clone NameClone OTI1E12 IsotypeIgG2b
Species ReactivityHuman Concentration0.81 mg/ml
Guaranteed Application *WB, IHC, IF, FC Suggested DilutionsWB 1:2000, IHC 1:50, IF 1:100, Flow 1:100
Predicted MW Explanation 58.2kDa
BufferPBS (PH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens cytochrome P450, family 1, subfamily A, polypeptide 2 (CYP1A2)
Alternative NameCP12; P3-450; P450(PA)
Database LinkNP_000752
Entrez Gene 1544 Human
FunctionThis gene encodes a member of the cytochrome P450 superfamily of enzymes. The cytochrome P450 proteins are monooxygenases which catalyze many reactions involved in drug metabolism and synthesis of cholesterol, steroids and other lipids. The protein encoded by this gene localizes to the endoplasmic reticulum and its expression is induced by some polycyclic aromatic hydrocarbons (PAHs), some of which are found in cigarette smoke. The enzyme's endogenous substrate is unknown; however, it is able to metabolize some PAHs to carcinogenic intermediates. Other xenobiotic substrates for this enzyme include caffeine, aflatoxin B1, and acetaminophen. The transcript from this gene contains four Alu sequences flanked by direct repeats in the 3' untranslated region.
Related PathwayTransmembraneP450Druggable Genome Caffeine metabolismTryptophan metabolismLinoleic acid metabolismRetinol metabolismMetabolism of xenobiotics by cytochrome P450Drug metabolism - cytochrome P450More Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CYP1A2 (RC221636, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CYP1A2.
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Immunohistochemical staining of paraffin-embedded liver tissue within the normal limits using anti-CYP1A2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501172, Dilution 1:50)
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Immunohistochemical staining of paraffin-embedded Carcinoma of liver tissue using anti-CYP1A2 mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA501172, Dilution 1:50)
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Anti-CYP1A2 mouse monoclonal antibody (TA501172) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY CYP1A2(RC221636).
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HEK293T cells transfected with either pCMV6-ENTRY CYP1A2(RC221636)(Red) or empty vector control plasmid(Blue) were immunostained with anti-CYP1A2 mouse monoclonal(TA501172), and then analyzed by flow cytometry.
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