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Anti-APP TRUEMAB Antibody Clone OTI7B8
TrueMAB Antibodies - Made against Authentic Protein Antigens
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|Full length human recombinant protein of human APP (NP_000475) produced in HEK293T cell.|
|WB, IHC, IF, FC
||WB 1:2000, IHC 1:50, IF 1:100, Flow 1:100
|PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.|
|Purified from mouse ascites fluids by affinity chromatography
|Homo sapiens amyloid beta precursor protein (APP), transcript variant 1|
|AAA; ABETA; ABPP; AD1; APPI; CTFgamma; CVAP; PN-II; PN2|
Entrez Gene 351 Human
|This gene encodes a cell surface receptor and transmembrane precursor protein that is cleaved by secretases to form a number of peptides. Some of these peptides are secreted and can bind to the acetyltransferase complex APBB1/TIP60 to promote transcriptional activation, while others form the protein basis of the amyloid plaques found in the brains of patients with Alzheimer disease. Mutations in this gene have been implicated in autosomal dominant Alzheimer disease and cerebroarterial amyloidosis (cerebral amyloid angiopathy). Multiple transcript variants encoding several different isoforms have been found for this gene.|
|TransmembraneDruggable Genome Alzheimer's disease|
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HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY APP (RC221339, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-APP.
Immunohistochemical staining of paraffin-embedded Kidney tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500978, Dilution 1:50)
Immunohistochemical staining of paraffin-embedded prostate tissue within the normal limits using anti-APP mouse monoclonal antibody. (Heat-induced epitope retrieval by 10mM citric buffer, pH6.0, 100C for 10min, TA500978, Dilution 1:50)
Anti-APP mouse monoclonal antibody (TA500978) immunofluorescent staining of COS7 cells transiently transfected by pCMV6-ENTRY APP(RC221339).
HEK293T cells transfected with either pCMV6-ENTRY APP(RC221339)(Red) or empty vector control plasmid(Blue) were immunostained with anti-APP mouse monoclonal(TA500978), and then analyzed by flow cytometry.