Anti-SLC7A8 Antibody, clone 7D6

Also for SLC7A8 (NM_012244)

Gene Name	Homo sapiens solute carrier family 7 (amino acid transporter light chain, L system), member 8 (SLC7A8), transcript variant 1
Synonyms:	LAT2; LPI-PC1
Immunogen	Protein expressed in 293T cell transfected with human SLC7A8 expression vector
Buffer	PBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Clone Name	clone 7D6	Isotype	IgG1
Species Reactivity	Human	Concentration	0.5~1.0 mg/ml (Lot Dependent)
Purification	Purified from mouse ascites fluids by affinity chromatography (Protein A or G Sepharose)
Guaranteed Application *	WB, IHC	Suggested Dilutions	WB 1:500, IHC 1:50,
Background	Sodium-independent, high-affinity transport of small and large neutral amino acids such as alanine, serine, threonine, cysteine, phenylalanine, tyrosine, leucine, arginine and tryptophan, when associated with SLC3A2/4F2hc. Acts as an amino acid exchanger. Has higher affinity for L-phenylalanine than LAT1 but lower affinity for glutamine and serine. L-alanine is transported at physiological concentrations. Plays a role in basolateral (re)absorption of neutral amino acids. Involved in the uptake of methylmercury (MeHg) when administered as the L-cysteine orD,L-homocysteine complexes, and hence plays a role in metal ion homeostasis and toxicity. Involved in the cellular activity of small molecular weight nitrosothiols, via the stereoselective transport of L-nitrosocysteine (L-CNSO) across the transmembrane. Plays an essential role in the reabsorption of neutral amino acids from the epithelial cells to the bloodstream in the kidney.
Related Pathway	Hemostasis

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WB Image

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY SLC7A8 (RC208586, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-SLC7A8.

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of breast tissue using anti-SLC7A8 mouse monoclonal antibody. (TA500515, Dilution 1:50)

IHC Image

Immunohistochemical staining of paraffin-embedded colon tissue using anti-SLC7A8mouse monoclonal antibody. (TA500515, Dilution 1:50)

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of colon tissue using anti-SLC7A8mouse monoclonal antibody. (TA500515, Dilution 1:50)

IHC Image

Immunohistochemical staining of paraffin-embedded Ovary tissue using anti-SLC7A8mouse monoclonal antibody. (TA500515, Dilution 1:50)

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of ovary tissue using anti-SLC7A8mouse monoclonal antibody. (TA500515, Dilution 1:50)

IHC Image

Immunohistochemical staining of paraffin-embedded pancreas tissue using anti-SLC7A8mouse monoclonal antibody. (TA500515, Dilution 1:50)

IHC Image

Immunohistochemical staining of paraffin-embedded Carcinoma of thyroid tissue using anti-SLC7A8mouse monoclonal antibody. (TA500515, Dilution 1:50)

IHC Image

Immunohistochemical staining of paraffin-embedded endometrium tissue using anti-SLC7A8mouse monoclonal antibody. (TA500515, Dilution 1:50)

IHC Image

Immunohistochemical staining of paraffin-embedded Adenocarcinoma of endometrium tissue using anti-SLC7A8mouse monoclonal antibody. (TA500515, Dilution 1:50)

IHC Image

Immunohistochemical staining of paraffin-embedded prostate tissue using anti-SLC7A8mouse monoclonal antibody. (TA500515, Dilution 1:50)

IHC Image

Immunohistochemical staining of paraffin-embedded Carcinoma of bladder tissue using anti-SLC7A8mouse monoclonal antibody. (TA500515, Dilution 1:50)

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Anti-SLC7A8 TrueMAB Antibody clone 7D6

TrueMAB™ Antibodies - Made against Authentic Protein Antigens