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Home Antibody All anti-CTNNB1 antibodies

Anti-CTNNB1 TRUEMAB Antibody Clone OTI2D11

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA500239 Beta-catenin mouse monoclonal antibody, clone OTI2D11 (formerly 2D11) 100ul $325 In Stock
LC419662 CTNNB1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
CF500239 Carrier-free (BSA/glycerol-free) Beta-catenin mouse monoclonal antibody, clone OTI2D11 (formerly 2D11) 100ug $450 3-4 weeks
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WB(2)
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Also for CTNNB1 (NM_001904)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenHuman recombinant protein fragment corresponding to amino acids 531-781 of human beta-catenin (NP_001895) produced in E.coli.
Clone NameClone OTI2D11 IsotypeIgG1
Species ReactivityHuman , Dog , Monkey Concentration0.3 mg/ml
Guaranteed Application *WB Suggested DilutionsWB 1:500~1000,
Predicted MW Explanation 85.3 kDa
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens catenin (cadherin-associated protein), beta 1, 88kDa (CTNNB1), transcript variant 1
Alternative Namearmadillo; CTNNB; MRD19
Database LinkNP_001895
Entrez Gene 1499 Human
Entrez Gene 574265 Monkey
Entrez Gene 477032 Dog
FunctionThe protein encoded by this gene is part of a complex of proteins that constitute adherens junctions (AJs). AJs are necessary for the creation and maintenance of epithelial cell layers by regulating cell growth and adhesion between cells. The encoded protein also anchors the actin cytoskeleton and may be responsible for transmitting the contact inhibition signal that causes cells to stop dividing once the epithelial sheet is complete. Finally, this protein binds to the product of the APC gene, which is mutated in adenomatous polyposis of the colon. Mutations in this gene are a cause of colorectal cancer (CRC), pilomatrixoma (PTR), medulloblastoma (MDB), and ovarian cancer. Three transcript variants encoding the same protein have been found for this gene.
Related PathwayES Cell Differentiation/IPSTranscription FactorsDruggable Genome Wnt signaling pathwayFocal adhesionAdherens junctionTight junctionLeukocyte transendothelial migrationMelanogenesisMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY CTNNB1 (RC208947, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-CTNNB1.
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Western blot analysis of extracts (35ug) from 9 different cell lines by using anti-CTNNB1 monoclonal antibody.
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