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Home Antibody All anti-STAT3 antibodies

Anti-STAT3 TRUEMAB Antibody clone 21E7

TrueMAB™ Antibodies - Made against Authentic Protein Antigens

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA500177
  • anti-STAT3 mouse monoclonal antibody,clone 21E7
  • FREE positive control: HEK293T cell transient overexpression lysate (LC403728) , 20ug
100ul 379 In Stock
CF500177
  • Carrier-free (BSA/glycerol-free) STAT3 mouse monoclonal antibody,clone 21E7
100ug $450 3 Days
Conjugation is available for this antibody: choose conjugation type
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WB(1)
IHC(8)
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Also for STAT3 (NM_213662)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant protein expressed in E.coli corresponding to amino acids 154-175 of human stat3
Clone Nameclone 21E7 IsotypeIgG1
Species ReactivityHuman Concentration0.35mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:500, IHC 1:50
BufferPBS (pH 7.3) containing 1% BSA, 50% glycerol and 0.02% sodium azide.
Purification Purified from mouse ascites fluids by affinity chromatography

Reference Data

Target NameHomo sapiens signal transducer and activator of transcription 3 (acute-phase response factor) (STAT3), transcript variant 3
Alternative NameAPRF; HIES
Database LinkNP_998827
FunctionThe protein encoded by this gene is a member of the STAT protein family. In response to cytokinesand growth factors, STAT family members are phosphorylated by the receptor associated kinases, andthen form homo- or heterodimers that translocate to the cell nucleus where they act astranscription activators. This protein is activated through phosphorylation in response to variouscytokines and growth factors including IFNs, EGF, IL5, IL6, HGF, LIF and BMP2. This proteinmediates the expression of a variety of genes in response to cell stimuli, and thus plays a keyrole in many cellular processes such as cell growth and apoptosis. The small GTPase Rac1 has beenshown to bind and regulate the activity of this protein. PIAS3 protein is a specific inhibitor ofthis protein. Three alternatively spliced transcript variants encoding distinct isoforms have beendescribed
Related Pathway
Adipogenesis
Delta-Notch Signaling Pathway
EGFR1 Signaling Pathway
Jak-STAT signaling pathway
TGF Beta Signaling Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
HEK293T cells were transfected with the pCMV6-ENTRY control (Left lane) or pCMV6-ENTRY STAT3(RC212394) (RC212394, Right lane) cDNA for 48 hrs and lysed. Equivalent amounts of cell lysates (5 ug per lane) were separated by SDS-PAGE and immunoblotted with anti-STAT3.
IHC Image
Immunohistochemical staining of paraffin-embedded breast using anti-STAT3 (TA500177) mouse monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded colon using anti-STAT3 (TA500177) mouse monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded kidney using anti-STAT3 (TA500177) mouse monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of kidney using anti-STAT3 (TA500177) mouse monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded lung using anti-STAT3 (TA500177) mouse monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of lung using anti-STAT3 (TA500177) mouse monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded Carcinoma of pancreas using anti-STAT3 (TA500177) mouse monoclonal antibody.
IHC Image
Immunohistochemical staining of paraffin-embedded thyroid using anti-STAT3 (TA500177) mouse monoclonal antibody.

 

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