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Home Antibody All anti-FLT3 antibodies

Anti-FLT3 Antibody Polyclonal

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA349523 Rabbit Polyclonal Anti-FLT3 Antibody 100ul $325 In Stock
LC418194 FLT3 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(2)

OriGene Data

ImmunogenFusion protein of human FLT3
Clone NamePolyclonal IsotypeIgG
Species ReactivityH,M,R Concentration1.2 mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsELISA: 1000-2000, WB: 200-1000, IHC: 25-100
Predicted MW Explanation 113 kDa
BufferpH7.4 PBS, 0.05% NaN3, 40% Glyceroln
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens fms related tyrosine kinase 3 (FLT3), transcript variant 1
Alternative NameCD135; FLK-2; FLK2; STK1
Database LinkNP_004110
FunctionThis gene encodes a class III receptor tyrosine kinase that regulates hematopoiesis. The receptor consists of an extracellular domain composed of five immunoglobulin-like domains, one transmembrane region, and a cytoplasmic kinase domain split into two parts by a kinase-insert domain. The receptor is activated by binding of the fms-related tyrosine kinase 3 ligand to the extracellular domain, which induces homodimer formation in the plasma membrane leading to autophosphorylation of the receptor. The activated receptor kinase subsequently phosphorylates and activates multiple cytoplasmic effector molecules in pathways involved in apoptosis, proliferation, and differentiation of hematopoietic cells in bone marrow. Mutations that result in the constitutive activation of this receptor result in acute myeloid leukemia and acute lymphoblastic leukemia.
Related PathwayProtein KinaseES Cell Differentiation/IPSTransmembraneDruggable Genome Cytokine-cytokine receptor interactionHematopoietic cell lineagePathways in cancerAcute myeloid leukemia

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Gel: 6%SDS-PAGE, Lysate: 40 ug, Lane 1-2: Lovo cells, 231 cells, Primary antibody: (FLT3 Antibody) at dilution 1/240, Secondary antibody: Goat anti rabbit IgG at 1/8000 dilution, Exposure time: 15 seconds
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IHC Image
The image on the left is immunohistochemistry of paraffin-embedded Human thyroid cancer tissue using (FLT3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
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IHC Image
The image on the left is immunohistochemistry of paraffin-embedded Human liver cancer tissue using (FLT3 Antibody) at dilution 1/30, on the right is treated with fusion protein. (Original magnification: ×200)
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