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Home Antibody All anti-SNCA antibodies

Anti-SNCA Antibody

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA337099 Chicken Polyclonal Synuclein-alpha Antibody 0.1ml $325 3-7 days
LC400127 SNCA HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IF(1)

OriGene Data

ImmunogenFull length human alpha-Synuclein [UniProt# P37840]
Clone Name Isotype
Species ReactivityRat Concentration1 mg/ml
Guaranteed Application *WB, IF Suggested DilutionsWB: 1:2000, IF: 1:1000,
Predicted MW Explanation 15 kDa
BufferPBS, 0.05% sodium Azide. Store at 4C short term. Aliquot and store at -20C long term. Avoid freeze-thaw cycles.
Purification Affinity purified
Note This alpha-Synuclein antibody is useful for Immunocytochemistry/Immunofluorescence and Western Blot, where a band can be seen at ~15 kDa.

Reference Data

Target Namesynuclein alpha
Alternative NameNACP|PARK1|PARK4|PD1
Database LinkNP_000336
Entrez Gene 0 Human
Entrez Gene 0 Mouse
Entrez Gene 29219 Rat
Entrez Gene 0 Monkey
Entrez Gene 0 Dog
FunctionAlpha-Synuclein is a member of the synuclein family, the other two proteins being beta and gamma synuclein. Alpha-Synuclein was originally isolated as a major synaptic vesicle associated protein from the electric organ of the fish Torpedo. Direct homologues of alpha-Synuclein are found in all vertebrates. Later work connected alpha-Synuclein with human brain pathology, when a protein originally identified as a component of NAC, the "Non-Amyloid beta Component of Alzheimer's disease amyloid" proved to be a peptide derived from alpha-Synuclein. The alpha-Synuclein protein is therefore sometimes known as NAC precursor or NACP. Further work showed that alpha-Synuclein is a major component of the Lewy bodies of Parkinson's disease and point mutations of alpha-Synuclein proved to be causative of some forms of familial Parkinson's disease. However, despite being discovered as a component of amyloid preparations, alpha-Synuclein is apparently not a major component of the senile plaques of Alzheimer's disease. Early onset Parkinson's disease may be caused by a duplication or triplication of one of the alpha-Synuclein genes. Alpha-Synuclein is also found in the Lewy bodies of patients with diffuse Lewy body disease and inclusions in glial cells in the brains of patients with multiple system atrophy (MSA) and amyotrophic lateral sclerosis (ALS). Alpha-Synuclein is heavily expressed in brain and appears to be localized primarily to presynaptic regions, though not with a typical synaptic vesicle distribution pattern. The synuclein proteins appear to have little 3D structure in solution, and probably belong to the family of "intrinsically unstructured proteins" which only adopt a well-defined conformation when bound to other proteins or membrane lipids.
Related PathwayDruggable Genome Alzheimer's diseaseParkinson's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Western Blot: alpha-Synuclein Antibody [TA337099] - Crude extract of rat brain, showing strong band at 15 kDa.
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IF Image
Immunocytochemistry/Immunofluorescence: alpha-Synuclein Antibody [TA337099] - Mixed rat neuron-glial cultures stained with TA337099, polyclonal antibody to alpha-Synuclein (red) and monoclonal antibody to MAP2 (NBP2-25156, green). The alpha-Synuclein anti
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