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Home Antibody All anti-HNRNPK antibodies

Anti-HNRNPK Antibody

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA332421 Rabbit anti-HNRNPK Polyclonal Antibody 100ug $325 3 weeks
LC400779 HNRNPK HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(3)
IF(2)
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Also for HNRNPK (NM_002140)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenRecombinant protein of human HNRNPK
Clone Name IsotypeIgG
Species ReactivityH M R Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB 1:500 - 1:2000;IHC 1:50 - 1:200;IF 1:50 - 1:200;IP 1:20 - 1:50;RIP 1:20 - 1:50
Predicted MW Explanation 51kDa
BufferStore at -20°C (regular) and -80°C (long term). Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3.
Purification Affinity purification

Reference Data

Target Nameheterogeneous nuclear ribonucleoprotein K
Alternative NameAUKS|CSBP|HNRPK|TUNP
Database LinkNP_002131
Entrez Gene 3190 Human
Entrez Gene 15387 Mouse
Entrez Gene 117282 Rat
Entrez Gene 0 Monkey
Entrez Gene 0 Dog
FunctionHeterogeneous nuclear ribonucleoprotein K (hnRNP K) belongs to a family of RNA binding multiprotein complexes (hnRNP proteins) that facilitate pre-mRNA processing and transport of mRNA from the nucleus to cytoplasm (1-3). hnRNP K contains three unique structural motifs termed KH domains that bind poly(C) DNA and RNA sequences (4,5). Intricate architecture enables hnRNP K to facilitate mRNA biosynthesis (6), transcriptional regulation (7), and signal transduction. Research studies have shown that cytoplasmic hnRNP K expression is increased in oral squamous cell carcinoma and pancreatic cancer, and may be a potential prognostic factor (8,9). hnRNP K coordinates with p53 to regulate its target gene transcription in response to DNA damage. Proteasome degradation of hnRNP K is mediated by E3 ligase MDM2 (10). The interaction between hnRNP K and c-Src leads to hnRNP K phosphorylation, which allows for hnRNP K activation of silenced mRNA translation (11).
Related Pathway Spliceosome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Western blot analysis of extracts of various cell lines, using HNRNPK antibody.
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IHC Image
Immunohistochemistry of paraffin-embedded rat lung using HNRNPK antibody at dilution of 1:100 (x400 lens).
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IHC Image
Immunohistochemistry of paraffin-embedded human esophageal using HNRNPK antibody at dilution of 1:100 (x400 lens).
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IHC Image
Immunohistochemistry of paraffin-embedded mouse heart using HNRNPK antibody at dilution of 1:100 (x400 lens).
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IF Image
Immunofluorescence analysis of MCF7 cell using HNRNPK antibody. Blue: DAPI for nuclear staining.
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IF Image
Immunofluorescence analysis of A549 cell using HNRNPK antibody.
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