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Home Antibody All anti-FEN1 antibodies

Anti-FEN1 Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326972
  • Rabbit anti-FEN1 Polyclonal Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC401328) , 20ug Explanation
100ug 325 3 Weeks
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WB(1)
IHC(1)
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Also for FEN1 (NM_004111)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenRecombinant protein of human FEN1
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC Suggested DilutionsWB 1:500 - 1:2000, IHC 1:50- 1:200
BufferStore at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification Affinity purification

Reference Data

Target NameHomo sapiens flap structure-specific endonuclease 1 (FEN1)
Alternative NameFEN-1; MF1; RAD2
Database LinkNP_004102
Entrez Gene 2237 Human
Entrez Gene 14156 Mouse
Entrez Gene 84490 Rat
FunctionFlap endonuclease-1 (FEN-1) is a structure-specific nuclease with multiple functions in DNA processing pathways. The replication and DNA repair activities of FEN-1 are critical for genomic stability in the eukaryotic cell. Through interaction with proliferation cell nuclear antigen (PCNA), FEN-1 helps coordinate Okazaki fragment maturation by removing RNA-DNA primers. FEN-1 is also required for non-homologous end joining of double stranded DNA breaks in long patch base excision repair. The multi-functional activities of FEN-1 are regulated by various mechanisms, including protein partner interactions, post-translational modifications, and subcellular re-localization in response to cell cycle or DNA damage.
Related PathwayStem cell - PluripotencyDruggable Genome DNA replicationBase excision repairNon-homologous end-joining

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of extracts of various cell lines, using FEN1 antibody.
IHC Image
Immunohistochemistry of paraffin-embedded human rectal cancer using FEN1 antibody at dilution of 1:200 (400x lens).

 

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