Home Antibody All anti-FEN1 antibodies
Also for FEN1 (NM_004111)
|Recombinant protein of human FEN1|
|Human, Mouse, Rat
||WB 1:500 - 1:2000, IHC 1:50- 1:200
|Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3|
|Homo sapiens flap structure-specific endonuclease 1 (FEN1)|
|FEN-1; MF1; RAD2|
Entrez Gene 2237 Human
Entrez Gene 14156 Mouse
Entrez Gene 84490 Rat
|Flap endonuclease-1 (FEN-1) is a structure-specific nuclease with multiple functions in DNA processing pathways. The replication and DNA repair activities of FEN-1 are critical for genomic stability in the eukaryotic cell. Through interaction with proliferation cell nuclear antigen (PCNA), FEN-1 helps coordinate Okazaki fragment maturation by removing RNA-DNA primers. FEN-1 is also required for non-homologous end joining of double stranded DNA breaks in long patch base excision repair. The multi-functional activities of FEN-1 are regulated by various mechanisms, including protein partner interactions, post-translational modifications, and subcellular re-localization in response to cell cycle or DNA damage.|
|Stem cell - PluripotencyDruggable Genome DNA replicationBase excision repairNon-homologous end-joining|
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Western blot analysis of extracts of various cell lines, using FEN1 antibody.
Immunohistochemistry of paraffin-embedded human rectal cancer using FEN1 antibody at dilution of 1:200 (400x lens).