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Home Antibody All anti-PARK7 antibodies

Anti-PARK7 Antibody

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SKU Description Amount Price Availability*  
TA326883
  • Rabbit anti-PARK7 Polyclonal Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC402122) , 20ug Explanation
100ug $325 3 Weeks
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WB(1)
IHC(1)
IF(1)
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Also for PARK7 (NM_007262)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenRecombinant protein of human PARK7
Clone Name IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1mg/ml
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB 1:500 - 1:2000, IHC 1:50- 1:200, ICC 1:20- 1:100, IF 1:50- 1:200, IP 1:20- 1:100
BufferStore at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
Purification Affinity purification

Reference Data

Target NameHomo sapiens parkinson protein 7 (PARK7), transcript variant 1
Alternative NameDJ-1; DJ1; HEL-S-67p
Database LinkNP_009193
Entrez Gene 11315 Human
Entrez Gene 57320 Mouse
Entrez Gene 117287 Rat
FunctionParkinsons disease (PD) is characterized by the presence of Lewy bodies (intracellular inclusions) and by the loss of dopaminergic neurons. Research studies have shown that mutations in a-synuclein, Parkin, and DJ-1 are linked to PD. a-synuclein is a major component of the aggregates found in Lewy bodies. Parkin is involved in protein degradation through the ubiquitin-proteasome pathway, and investigators have shown that mutations in Parkin cause early onset of PD. Loss-of-function mutations in DJ-1 cause early onset of PD, but DJ-1 is associated with multiple functions: it cooperates with Ras to increase cell transformation, it positively regulates transcription of the androgen receptor, and it may function as an indicator of oxidative stress. Dopamine D2 receptor-mediated functions are greatly impaired in DJ-1 (-/-) mice, resulting in reduced long-term depression.
Related PathwayProteaseDruggable Genome Parkinson's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of Jurkat cell lysate using PAPK7 antibody.
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Immunohistochemistry of paraffin-embedded human kidney using PARK7 antibody at dilution of 1:200 (400x lens).
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Immunofluorescence analysis of HeLa cell using PARK7 antibody. Blue: DAPI for nuclear staining.
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