Home Antibody All anti-PARK7 antibodies
Also for PARK7 (NM_007262)
|Recombinant protein of human PARK7|
|Human, Mouse, Rat
|WB, IHC, IF
||WB 1:500 - 1:2000, IHC 1:50- 1:200, ICC 1:20- 1:100, IF 1:50- 1:200, IP 1:20- 1:100
|Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3|
|Homo sapiens parkinson protein 7 (PARK7), transcript variant 1|
|DJ-1; DJ1; HEL-S-67p|
Entrez Gene 11315 Human
Entrez Gene 57320 Mouse
Entrez Gene 117287 Rat
|Parkinsons disease (PD) is characterized by the presence of Lewy bodies (intracellular inclusions) and by the loss of dopaminergic neurons. Research studies have shown that mutations in a-synuclein, Parkin, and DJ-1 are linked to PD. a-synuclein is a major component of the aggregates found in Lewy bodies. Parkin is involved in protein degradation through the ubiquitin-proteasome pathway, and investigators have shown that mutations in Parkin cause early onset of PD. Loss-of-function mutations in DJ-1 cause early onset of PD, but DJ-1 is associated with multiple functions: it cooperates with Ras to increase cell transformation, it positively regulates transcription of the androgen receptor, and it may function as an indicator of oxidative stress. Dopamine D2 receptor-mediated functions are greatly impaired in DJ-1 (-/-) mice, resulting in reduced long-term depression.|
|ProteaseDruggable Genome Parkinson's disease|
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Western blot analysis of Jurkat cell lysate using PAPK7 antibody.
Immunohistochemistry of paraffin-embedded human kidney using PARK7 antibody at dilution of 1:200 (400x lens).
Immunofluorescence analysis of HeLa cell using PARK7 antibody. Blue: DAPI for nuclear staining.