Angiopoietin 2 (ANGPT2) Rabbit Polyclonal Antibody

CAT#: TA326854

Rabbit anti-ANGPT2 Polyclonal Antibody

Product Images

Western blot analysis of HepG2 cell lysate using ANGPT2 antibody.

• 

  Immunofluorescence analysis of HeLa cell using ANGPT2 antibody. Blue: DAPI for nuclear staining.

Specifications

Product Data

• Applications: ICC/IF, WB
• Recommended Dilution: WB 1:500 - 1:2000;IF 1:50 - 1:200
• Reactivities: Human, Mouse, Rat
• Host: Rabbit
• Isotype: IgG
• Clonality: Polyclonal
• Immunogen: Recombinant protein of human ANGPT2
• Formulation: Store at -20C or -80C. Avoid freeze / thaw cycles. Buffer: PBS with 0.02% sodium azide, 50% glycerol, pH7.3
• Concentration: lot specific
• Purification: Affinity purification
• Conjugation: Unconjugated
• Storage: Store at -20°C as received.
• Stability: Stable for 12 months from date of receipt.
• Predicted Protein Size: 57 kDa
• Gene Name: angiopoietin 2
• Database Link:
  NP_001138
  Entrez Gene 11601 MouseEntrez Gene 89805 RatEntrez Gene 285 Human
  UniProt ID O15123
• Background: Angiopoietins are a family of Tie receptor ligands. There are four angiopoietins discovered so far: angiopoietins 1, 2, 3 and 4 (Ang1, 2, 3, and 4). Ang1 binds to the Tie-2 receptor and leads to its autophosphorylation and subsequent activation of downstream signaling pathways. It plays an important role in blood vessel formation, maturation and subsequent stabilization. Ang2 is an endothelium-specific growth factor that functions as an antagonist to Ang1, promotes vascular associated proinflammatory function, destabilizes quiescent endothelium, leads to vascular leakage and vascular destablization and remodeling. Ang2 is selectively expressed in many tumor tissues where, combined with other growth factors such as VEGF, it can promote vascular remodeling, angiogenesis and inflammation.
• Synonyms: AGPT2; ANG2

Reference Data

• Protein Families: Druggable Genome, Secreted Protein