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Home Antibody All anti-Hcn2 antibodies

Anti-Hcn2 Antibody S71-37

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326544
  • Mouse Monoclonal Anti-HCN2 Antibody
100µg 325 In Stock
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IF(1)

OriGene Data

ImmunogenFusion protein amino acids 761-863 of rat HCN2,
Clone NameS71-37 IsotypeIgG1
Species ReactivityHuman, Mouse, Rat Concentration1mg/mL
Guaranteed Application *IF Suggested DilutionsWB: 1-10ug/ml, IHC: 0.1-1.0ug/ml, IF: 1.0-10ug/ml
BufferPBS pH7.4, 50% glycerol
Purification Protein G Purified
Note Detects ~95kDa. No cross-reactivity against HCN1

Reference Data

Target NameRattus norvegicus hyperpolarization activated cyclic nucleotide-gated potassium channel 2 (Hcn2)
Alternative Name
Database LinkNP_446136
Entrez Gene 610 Human
Entrez Gene 15166 Mouse
Entrez Gene 114244 Rat
FunctionHyperpolarization-activated cyclic nucleotide-gated ion channel 2 (HCN2) is an integral membrane protein that helps establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient . Ion channels are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels . Specifically, hyperpolarization-activated cation channels of the HCN gene family contribute to spontaneous rhythmic activity in both the heart and brain .
Related Pathway

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IF Image
IF analysis of HCN2 in human hippocampal tissues using the antibody

 

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