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Anti-Dlg2 Antibody S18-30
Also for Dlg2 (NM_022282)
|Fusion protein amino acids 1-852 of rat Chapsyn-110; |
|Human (weak), Mouse, Rat
||WB: 1-10ug/ml, IHC: 0.1-1.0ug/ml, IF: 1.0-10ug/ml
|PBS pH7.4, 50% glycerol|
|Protein G Purified
|Detects ~110kDa. No cross-reactivity against other MAGUK family members, PSD95, SAP97, SAP102, expressed in transfected cells.
|Rattus norvegicus discs, large homolog 2 (Drosophila) (Dlg2)|
|Chapsyn-110, is a part of the membrane-associated putative guanylate kinase (MAGUK) family. It binds directly to the NMDA receptor, and Shaker K+ channel subunits, and is 70-80% identical to PSD-95/SAP90 and SAP97 . It associated tightly with the postsynaptic density I brain, and mediates the clustering of both NMDA recpetors and K+ channels in heterologous cells. The encoded protein forms a heterodimer with PSD-95 that may interact at postsynaptic sites to form a multimeric scaffold for the clustering of receptors, ion channels, and associated signaling proteins .|
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Western blot analysis of Chapsyn-110 in rat brain membrane lysates using a 1:1000 dilution of the antibody