Invalid object name 'antibody_LocusMapping'. Anti-Kcnj2 Antibody, S112B-14 - OriGene
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Anti-Kcnj2 Antibody S112B-14

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326486
  • Mouse Monoclonal Anti-Kir2.1 Antibody
100µg 325 3-7 Days
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WB(1)
IF(1)

OriGene Data

ImmunogenSynthetic peptide amino acids 390-411 (cytoplasmic C-terminus) of course Kir2.1
Clone NameS112B-14 IsotypeIgG1
Species ReactivityMouse, Rat Concentration1mg/mL
Guaranteed Application *WB, IF Suggested DilutionsWB: 1-10ug/ml, IHC: 0.1-1.0ug/ml, IF: 1.0-10ug/ml
BufferPBS pH7.4, 50% glycerol, 0.09% sodium azide
Purification Protein G Purified
Note Detects ~55kDa. No cross-reactivity against Kir2.2 or Kir2.3

Reference Data

Target NameMus musculus potassium inwardly-rectifying channel, subfamily J, member 2 (Kcnj2)
Alternative NameIRK1; Kcnf1; Kir2.1
Database LinkNP_032451
FunctionIon channels are integral membrane proteins that help establish and control the small voltage gradient across the plasma membrane of living cells by allowing the flow of ions down their electrochemical gradient . They are present in the membranes that surround all biological cells because their main function is to regulate the flow of ions across this membrane. Whereas some ion channels permit the passage of ions based on charge, others conduct based on a ionic species, such as sodium or potassium. Furthermore, in some ion channels, the passage is governed by a gate which is controlled by chemical or electrical signals, temperature, or mechanical forces.There are a few main classifications of gated ion channels. There are voltage- gated ion channels, ligand- gated, other gating systems and finally those that are classified differently, having more exotic characteristics. The first are voltage- gated ion channels which open and close in response to membrane potential. These are then separated into sodium, calcium, potassium, proton, transient receptor, and cyclic nucleotide-gated channels; each of which is responsible for a unique role. Ligand-gated ion channels are also known as ionotropic receptors, and they open in response to specific ligand molecules binding to the extracellular domain of the receptor protein. The other gated classifications include activation and inactivation by second messengers, inward-rectifier potassium channels, calcium-activated potassium channels, two-pore-domain potassium channels, light-gated channels, mechano-sensitive ion channels and cyclic nucleotide-gated channels. Finally, the other classifications are based on less normal characteristics such as two-pore channels, and transient receptor potential channels .The Kir2.1 inward-rectifier potassium ion channel is encoded by the KCNJ2 gene. A defect in this gene is associated with Andersen-Tawil syndrome .
Related Pathway

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WB Image
Western blot analysis of Kir2.1 in COS transient cells using a 1:1000 dilution of the antibody
IF Image
IF analysis of Kir2.1 in mouse backskin sections. Courtesy of Dr. Turksen, Ottawa Hospital Research Institute, Canada.

 

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