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Home Antibody All anti-HSPA5 antibodies

Anti-HSPA5 Antibody 6H4.2G7


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA326480 Mouse Monoclonal Anti-Grp78 Antibody 100µg $325 3-7 Days
LC417364 HSPA5 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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Also for HSPA5 (NM_005347)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenHis-tagged human GRP78
Clone Name6H4.2G7 IsotypeIgG1
Species ReactivityHuman. Other species not yet tested. Concentration1mg/mL
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:2000
BufferPBS pH7.4, 50% glycerol, 0.09% sodium azide
Purification Protein G Purified
Note Detects a protein with a mass of ~78kDa corresponding to GRP78

Reference Data

Target NameHomo sapiens heat shock protein family A (Hsp70) member 5 (HSPA5)
Alternative NameBIP; GRP78; HEL-S-89n; MIF2
Database LinkNP_005338
Entrez Gene 3309 Human
FunctionGRP78 is a ubiquitously expressed, 78-kDa glucose- regulated protein, and is commonly referred to as an immunoglobin chain binding protein (BiP). The BiP proteins are categorized as stress response proteins because they play an important role in the proper folding and assembly of nascent protein and in the scavenging of misfolded proteins in the endoplasmic reticulum lumen. Translation of BiP is directed by an internal ribosomal entry site (IRES) in the 5 nontranslated region of the BiP mRNA. BiP IRES activity increases when cells are heat stressed .GRP78 is also critical for maintenance of cell homeostasis and the prevention of apoptosis . Luo et al. have provided findings that suggest GRP78 is essential for embryonic cell growth and pluripotent cell survival .In terms of diseases, GRP78 has been shown to be a reliable biomarker of hypoglycemia, to serve a neuroprotective function in neurons exposed to glutamate and oxidative stress , and its protein levels are reduced in the brains of Alzheimers patients . Also, the induction of the GRP78 protein that results in severe glucose and oxygen deprivation could possible lead to drug resistance to anti-tumor drugs .
Related PathwayDruggable Genome Antigen processing and presentationPrion diseases

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
0.5 µg/ml of TA309343 was sufficient for detection of Grp78 in 10ug of HeLa cell lysate by ECL immunoblot analysis.

IHC Image
IHC analysis of Grp78 using the antibody


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