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Home Antibody All anti-DLG4 antibodies

Anti-DLG4 Antibody S28-43

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA326433
  • Mouse monoclonal PSD95 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC419977) , 20ug Explanation
100µg 325 3-7 Days
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IHC(1)
IF(1)
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Also for DLG4 (NM_001365)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenFusion protein amino acids 77-200 of human PSD95/SAP90
Clone NameS28-43 IsotypeIgG2a
Species ReactivityMouse, Rat, Human Concentration1mg/mL
Guaranteed Application *IHC, IF Suggested DilutionsWB: 1:1000
BufferPBS pH7.4, 50% glycerol, 0.09% sodium azide
Purification Protein G Purified
Note Detects ~95-110kDa.

Reference Data

Target NameHomo sapiens discs, large homolog 4 (Drosophila) (DLG4), transcript variant 1
Alternative NamePSD95; SAP-90; SAP90
Database LinkNP_001356
Entrez Gene 1742 Human
Entrez Gene 13385 Mouse
Entrez Gene 29495 Rat
FunctionPostsynaptic Density protein 95 (PSD95), also known as Synapse associated protein 90kDa, is a member of the membrane-associated guanylate kinase (MAGUK) family of proteins. PSD95 is a scaffolding protein and is involved in the assembly and function of the postsynaptic density complex . These family members consist of an N-terminal variable segment followed by three amino-terminal PDZ domains, an upstream SH3 domain and an inactive carboxyl-terminal guanylate kinase (GK) domain. The first and second PDZ domain localize NMDA receptors and K+ channels to synapses, and the third binds toneuroligins which are neuronal cell adhesion molecules that interact with b-neurexins and form intercellular junctions. PSD-95 also binds to neuronal nitric oxide synthase, possibly through interactions between PDZ domains present on both proteins . Thus different PDZ domains of PSD-95 might be specialized for distinct functions .PSD95 participates in synaptic targeting of AMPA receptors through an indirect manner involving Stargazin and related transmembrane AMPA receptor regulatory proteins (TARPs) . The protein is implicated in experience dependent plasticity and plays an indispensable role in learning . Mutations in PSD95 are associated with autism .
Related PathwayDruggable Genome Huntington's disease

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

IHC Image
Immunolabelling of PSD95 using a dilution of the antibody
IF Image
IF of PSD95 in cultures of dissociated hippocampal neurons. Cultures were grown and labeled with antibodies against the indicated proteins. A neuron double stained for PSD95.

 

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