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Home Antibody All anti-AKT2 antibodies

Anti-AKT2 Antibody N/A


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SKU Description Amount Price Availability*  
TA326431 Rabbit polyclonal Akt2 (PKB beta) Antibody 400ul $325 3-7 Days
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OriGene Data

ImmunogenA five residue synthetic peptide based on the human Akt2, coupled to KLH
Clone NameN/A Isotype
Species ReactivityHuman, Mouse, Rat, Bovine, Chicken, Dog, Guinea Pig, Hamster, Monkey, Pig, Rabbit, Sheep, Xenopus. Concentration0.25mg/mL
Guaranteed Application *WB Suggested Dilutions1:3000 dilution was sufficient for detection of PKBß in 20ug of HeLa cell lysate by ECL immunoblot analysis.
BufferTBS, 50% glycerol, 0.09% sodium azide
Purification Affinity Purified
Note Detects a 65kDa protein, corresponding to the molecular mass of Akt2 PKBß on SDS PAGE immunoblots. Does not react with PKBa (Akt1) or PKB? (Akt3).

Reference Data

Target NameHomo sapiens v-akt murine thymoma viral oncogene homolog 2 (AKT2), transcript variant 1
Database LinkNP_001617
Entrez Gene 208 Human
Entrez Gene 11652 Mouse
Entrez Gene 25233 Rat
Entrez Gene 700591 Monkey
Entrez Gene 449021 Dog
FunctionProtein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises three highly homologous members known as PKB alpha (Akt1), PKB beta (Akt2) and PKB gamma (Akt3). PKB/Akt is a growth-factor-regulated protein kinase which contains a Pleckstrin Homology (PH) domain which might be important for dimerization of the kinase. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1) and PDK2 . Myelin basic protein and histone H2B are in vitro substrates for PKB, while glycogen synthase kinase-3 has been implicated as a physiological target . Key roles for this enzyme can be found in cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration .
Related PathwayProtein KinaseES Cell Differentiation/IPSDruggable Genome MAPK signaling pathwayErbB signaling pathwayChemokine signaling pathwaymTOR signaling pathwayApoptosisVEGF signaling pathwayMore Pathways >>

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WB Image
Western blot analysis of AKT2 (PKBbeta) in cell line mix using a 1:1000 dilution of the antibody


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