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Anti-AKT2 TRUEMAB Antibody N/A
Also for AKT2 (NM_001626)
|A five residue synthetic peptide based on the human Akt2, coupled to KLH|
|Human, Mouse, Rat, Bovine, Chicken, Dog, Guinea Pig, Hamster, Monkey, Pig, Rabbit, Sheep, Xenopus.
||1:3000 dilution was sufficient for detection of PKBß in 20ug of HeLa cell lysate by ECL immunoblot analysis.
|TBS, 50% glycerol, 0.09% sodium azide|
|Detects a 65kDa protein, corresponding to the molecular mass of Akt2 PKBß on SDS PAGE immunoblots. Does not react with PKBa (Akt1) or PKB? (Akt3).
|Homo sapiens v-akt murine thymoma viral oncogene homolog 2 (AKT2), transcript variant 1|
|HIHGHH; PKBB; PKBBETA; PRKBB; RAC-BETA|
|Protein kinase B or Akt (PKB/Akt) is a serine/threonine kinase, which in mammals comprises three highly homologous members known as PKB alpha (Akt1), PKB beta (Akt2) and PKB gamma (Akt3). PKB/Akt is a growth-factor-regulated protein kinase which contains a Pleckstrin Homology (PH) domain which might be important for dimerization of the kinase. Binding of phosphoinositide 3-OH kinase products to the pleckstrin homology domain results in translocation of PKB/Akt to the plasma membrane where it is activated by phosphorylation by upstream kinases including the phosphoinoside-dependent kinase 1 (PDK1) and PDK2 . Myelin basic protein and histone H2B are in vitro substrates for PKB, while glycogen synthase kinase-3 has been implicated as a physiological target . Key roles for this enzyme can be found in cellular processes such as glucose metabolism, cell proliferation, apoptosis, transcription and cell migration .|
Jak-STAT signaling pathway
MAPK signaling pathway
Signaling by GPCR
Toll-like receptor signaling pathway
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Western blot analysis of AKT2 (PKBbeta) in cell line mix using a 1:1000 dilution of the antibody