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Home Antibody All anti-HspB8 antibodies

Anti-HspB8 Antibody N/A


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA326395 Rabbit polyclonal Hsp22 Antibody 100ul $325 3-7 Days
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OriGene Data

ImmunogenHuman Hsp22
Clone NameN/A Isotype
Species ReactivityHuman, Mouse, Rat. Not yet tested on other species. ConcentrationN/A
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000
BufferRabbit antiserum
Purification Rabbit antiserum
Note Detects ~22kDa. Does not cross-react with Hsp27 or alpha-crystallin.

Reference Data

Target NameG protein nucleolar 3
Alternative NameC77032|E2IG3|NNP47|NS
Database LinkNP_996562
Entrez Gene 26353 Human
Entrez Gene 80888 Mouse
Entrez Gene 113906 Rat
FunctionHsp22 (HSPB8) is a 196-amino acid protein that is a member of the small heat shock protein super-family and the human protein is most closely related to Hsp27. Similar to most other sHSPs, Hsp22 is predominately transcribed in skeletal muscle and heart, as well as the placenta . Hsp22 is a monomeric protein which interacts with HSPB1. It displays temperature-dependent chaperone activity. In a two hybrid screen, HspB8 interacted preferentially with a triple aspartate form of Hsp27 which mimics Hsp27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type Hsp27 . HSPB8 has two binding domains (N and C Terminal) that are specific for different binding partners, and has the ability to bind itself and other sHSPs . The chaperone-like activity is of great importance to the function of Hsp22 in various processes including proliferation, apoptosis and macroautophagy . Mutations in the HSPB8 gene are associated with the inherited peripheral neurpathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L) .
Related PathwayES Cell Differentiation/IPSStem cell - Pluripotency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Hsp22 in rat skeletal muscle lysates using 20ug of the antibody

IHC Image
IHC analysis of Hsp22 using the antibody


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