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Home Antibody All anti-HspB8 antibodies

Anti-HspB8 Antibody N/A

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Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA326395 Rabbit polyclonal Hsp22 Antibody 100ul $325 3-7 Days
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WB(1)
IHC(1)

OriGene Data

ImmunogenHuman Hsp22
Clone NameN/A Isotype
Species ReactivityHuman, Mouse, Rat. Not yet tested on other species. ConcentrationN/A
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:1000
BufferRabbit antiserum
Purification Rabbit antiserum
Note Detects ~22kDa. Does not cross-react with Hsp27 or alpha-crystallin.

Reference Data

Target NameG protein nucleolar 3
Alternative NameC77032|E2IG3|NNP47|NS
Database LinkNP_996562
Entrez Gene 26353 Human
Entrez Gene 80888 Mouse
Entrez Gene 113906 Rat
FunctionHsp22 (HSPB8) is a 196-amino acid protein that is a member of the small heat shock protein super-family and the human protein is most closely related to Hsp27. Similar to most other sHSPs, Hsp22 is predominately transcribed in skeletal muscle and heart, as well as the placenta . Hsp22 is a monomeric protein which interacts with HSPB1. It displays temperature-dependent chaperone activity. In a two hybrid screen, HspB8 interacted preferentially with a triple aspartate form of Hsp27 which mimics Hsp27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type Hsp27 . HSPB8 has two binding domains (N and C Terminal) that are specific for different binding partners, and has the ability to bind itself and other sHSPs . The chaperone-like activity is of great importance to the function of Hsp22 in various processes including proliferation, apoptosis and macroautophagy . Mutations in the HSPB8 gene are associated with the inherited peripheral neurpathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L) .
Related PathwayES Cell Differentiation/IPSStem cell - Pluripotency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.


WB Image
Western blot analysis of Hsp22 in rat skeletal muscle lysates using 20ug of the antibody
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IHC Image
IHC analysis of Hsp22 using the antibody
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