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Home Antibody All anti-HspB8 antibodies

Anti-HspB8 Antibody 3C12-H11


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA326394 Mouse monoclonal Hsp22 Antibody 100µg $325 3-7 Days
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OriGene Data

ImmunogenHis-tagged human recombinant hsp22
Clone Name3C12-H11 IsotypeIgG1 Kappa
Species ReactivityHuman, Mouse, Rat Concentration1mg/mL
Guaranteed Application *WB, IHC Suggested DilutionsWB: 1:2000
BufferPBS pH7.4, 50% glycerol, 0.09% sodium azide
Purification Protein G Purified
Note Detects endogenous and exogenous hsp22 in monomeric, dimeric and tetrameric forms in WB. Does not cross react with alpha crystallin.

Reference Data

Target NameG protein nucleolar 3
Alternative NameC77032|E2IG3|NNP47|NS
Database LinkNP_996562
Entrez Gene 26353 Human
Entrez Gene 80888 Mouse
Entrez Gene 113906 Rat
FunctionHsp22 (HSPB8) is a 196-amino acid protein that is a member of the small heat shock protein super-family and the human protein is most closely related to Hsp27. Similar to most other sHSPs, Hsp22 is predominately transcribed in skeletal muscle and heart, as well as the placenta . Hsp22 is a monomeric protein which interacts with HSPB1. It displays temperature-dependent chaperone activity. In a two hybrid screen, HspB8 interacted preferentially with a triple aspartate form of Hsp27 which mimics Hsp27 phosphorylated at Ser15, Ser78, and Ser82, as compared to wild-type Hsp27 . HSPB8 has two binding domains (N and C Terminal) that are specific for different binding partners, and has the ability to bind itself and other sHSPs . The chaperone-like activity is of great importance to the function of Hsp22 in various processes including proliferation, apoptosis and macroautophagy . Mutations in the HSPB8 gene are associated with the inherited peripheral neurpathies, autosomal dominant distal hereditary motor neuropathy type IIA (dSMA) and axonal Charcot-Marie-Tooth disease type 2L (CMT2L) .
Related PathwayES Cell Differentiation/IPSStem cell - Pluripotency

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of Hsp22 in rat tissue mix using a 1:1000 dilution of the antibody

IHC Image
IHC analysis of Hsp22, tested on mouse backskin sections. Courtesy of Dr. Turksen, Ottawa Hospital Research Institute.


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