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Anti-FKBP5 Antibody Hi51B
Also for FKBP5 (NM_004117)
|Synthetic peptide corresponding to the residues of human FKBP51|
|Canine, Hamster, Human, Mouse, Rat, Rabbit
|PBS, 50% glycerol|
|Protein G Purified
|Detects an ~51kDa protein representing FKBP51 in cell lysate. Also detects FKBP51 in whole tissue extracts from rat kidney and rat and mouse testes.
|Homo sapiens FK506 binding protein 5 (FKBP5), transcript variant 1|
|AIG6; FKBP51; FKBP54; P54; PPIase; Ptg-10|
|Hsp90 is crucial to cellular signaling by its regulation of the folding, activity, and stability of a wide range of client proteins. These client protein complexes may also contain one or more cochaperones . One class of Hsp90-binding cochaperone is composed of proteins with a characteristic tetratricopeptide repeat (TPR) domain that forms an Hsp90 binding site. Among the TPR cochaperones of Hsp90 are Hop/Sti1, protein phosphatase PP5, and members of both the FK506- and cyclosporin A-binding families of immunophilins . FK506-binding protein 51 (FKBP51) and FKBP52 are large molecular weight immunophilins that are part of the mature glucocorticoid receptor (GR) heterocomplex . The N terminal domain of each protein binds FK506 and has peptidyl-prolyl isomerase (PPIase) activity that converts prolyl peptide bonds within target proteins from cis- to trans- proline. The C-terminal domains contain the TPR repeats involved in protein-protein interactions with the Hsp90 . Although FKBP52 and FKBP51 share ~75% sequence similarity, they affect hormone binding by glucocorticoid receptor in opposing manners and have different Hsp90-binding characteristics . FK506 binding protein 51 kDa (FKBP51 or otherwise referred to as FKBP54) has been identified as a progestininducible gene. This protein is predominantly expressed in murine T cells but in humans, it is abundantly expressed in numerous tissues at levels many times higher than FKBP12. The FKBP51 gene is known to be induced by glucocorticoids .|
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Western blot analysis of FKBP51 in HeLa cell lysates, using a 1:1000 dilution of the antibody
IF localization of FKBP51 antibody in normal MK cells (shown in red). Courtesy of the Hospital Henri Mondor, France.