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Anti-MAPK14 Antibody 9F12
Also for MAPK14 (NM_001315)
|Full length recombinant protein expressed in E.coli cells.|
|Human, Rat. Other species not yet tested.
|PBS, 50% glycerol|
|Protein G Purified
|Detects a ~38kDa protein corresponding to the molecular mass of p38a MAPK on SDS PAGE immunoblots.
|Homo sapiens mitogen-activated protein kinase 14 (MAPK14), transcript variant 1|
|CSBP; CSBP1; CSBP2; CSPB1; EXIP; Mxi2; p38; p38ALPHA; PRKM14; PRKM15; RK; SAPK2A|
|The MAPK (mitogen activated protein kinase) comprises a family of ubiquitous praline-directed, proteinserine/ threonine kinases which signal transduction pathways that control intracellular events including acute responses to hormones and major developmental changes in organisms . This super family consists of stress activated protein kinases (SAPKs); extracellular signal-regulated kinases (ERKs); and p38 kinases, each of which forms a separate pathway . The kinase members that populate each pathway are sequentially activated by phosphorylation. Upon activation, p38 MAPK/SAPK2 translocates into the nucleus where it phosphorylates one or more nuclear substrates, effecting transcriptional changes and other cellular processes involved in cell growth, division, differentiation, inflammation, and death . Specifically p38 always acts as a pro-apoptotic factor with its activation leading to the release of cytochrome c from mitochondria and cleavage of caspase 3 and its downstream effector, PARP . p38 MAPK is activated by a variety of chemical stress inducers including hydrogen peroxide, heavy metals, anisomycin, sodium salicylate, LPS, and biological stress signals such as tumor necrosis factor, interleukin-1, ionizing and UV irradiation, hyperosmotic stress and chemotherapeutic drugs . As a result, p38 alpha has been widely validated as a target for inflammatory disease including rheumatoid arthritis, COPD and psoriasis and has also been implicated in cancer, CNS and diabetes .|
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Multi-blot analysis of p38Alpha MAPKinase in cell lysate from 12 human cancer cell lines using a 1:1000 dilution of the antibody
p38 MAPKinase visualized on a retinal injury model using the antibody