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Anti-CTTN PHOSPHO Antibody


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA324049 Anti-CTTN (Phospho-Tyr466) Rabbit Polyclonal Antibody 100ul 325
2-3 Weeks
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OriGene Data

ImmunogenPeptide sequence around phosphorylation site of tyrosine 466 (P-V-Y(p)-E-T) derived from Human CORTACTIN.
Clone Name IsotypeIgG
Species ReactivityHuman; Mouse Concentration1mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 1:500-1000
Predicted MW Explanation 85kDa
BufferPBS pH7.3, 0.05% NaN3, 50% glycerol
Purification Antigen affinity purification

Reference Data

Target NameHomo sapiens cortactin (CTTN), transcript variant 2
Alternative NameEMS1
Database LinkNP_612632
Entrez Gene 2017 Human
Entrez Gene 13043 Mouse
FunctionCortactin is overexpressed in breast cancer and squamous cell carcinomas of the head and neck. The encoded protein is localized in the cytoplasm and in areas of the cell-substratum contacts. This gene has two roles: (1) regulating the interactions between components of adherens-type junctions and (2) organizing the cytoskeleton and cell adhesion structures of epithelia and carcinoma cells. During apoptosis, the encoded protein is degraded in a caspase-dependent manner. The aberrant regulation of this gene contributes to tumor cell invasion and metastasis. Two splice variants that encode different isoforms have been identified for this gene.
Related PathwayDruggable Genome Tight junctionPathogenic Escherichia coli infection

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Predicted band size: 85 kDa . Positive control: Jurkat cells treated with H2O2 lysate. Recommended dilution: 1/ 500-1000. (Gel: 8%SDS-PAGE Lane1: Jurkat cells untreated with H2O2 lysate Lane2: Jurkat cells treated with H2O2 lysate Lysates: 30 ug per lane Primary antibody: 1/500 dilution Secondary antibody: Goat anti Rabbit IgG - H&L (HRP) at 1/10000 dilution Exposure time: 1 minute)


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