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Anti-HLA-E Antibody 3D12HLA-E
Also for HLA-E (NM_005516)
||0.5-1mg/ml (lot dependent)
||Flow, IP, WB
|Aqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer|
|Homo sapiens major histocompatibility complex, class I, E (HLA-E)|
|EA1.2; EA2.1; HLA-6.2; MHC; QA1|
|The monoclonal antibody 3D12 (HLA-E) recognizes human HLA-E, a member of the Human Leukocyte Antigen family. HLA-E is a MHC Class IB member, which has a specialized role in NK cell recognition. Binding of a restricted set of peptides derived from other Class I leader sequences to the HLA-E and B2M (beta2 microglobulin) complex leads to interaction with NKG2A on NK cells. This binding protects the HLA-G-expressing cell from NK cell killing. HLA-E expression is ubiquitous.|
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Staining of normal human peripheral blood cells with 0.5 ug of Mouse IgG1 K Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human HLA-E Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE . Cells in the lymphocyte gate were used for analysis.