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Home Antibody All anti-HLA-E antibodies

Anti-HLA-E Antibody 3D12HLA-E

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA320346
  • Mouse Anti-Human HLA-E Purified (25 ug)
25ug 120 3-7 Days
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FC(1)
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Also for HLA-E (NM_005516)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

Immunogen
Clone Name3D12HLA-E Isotype
Species ReactivityHuman Concentration0.5-1mg/ml (lot dependent)
Guaranteed Application *FC Suggested DilutionsFlow, IP, WB
BufferAqueous buffer, 0.09% sodium azide, may contain carrier protein/stabilizer
Purification Affinity purified

Reference Data

Target NameHomo sapiens major histocompatibility complex, class I, E (HLA-E)
Alternative NameEA1.2; EA2.1; HLA-6.2; MHC; QA1
Database LinkNP_005507
Entrez Gene 3133 Human
FunctionThe monoclonal antibody 3D12 (HLA-E) recognizes human HLA-E, a member of the Human Leukocyte Antigen family. HLA-E is a MHC Class IB member, which has a specialized role in NK cell recognition. Binding of a restricted set of peptides derived from other Class I leader sequences to the HLA-E and B2M (beta2 microglobulin) complex leads to interaction with NKG2A on NK cells. This binding protects the HLA-G-expressing cell from NK cell killing. HLA-E expression is ubiquitous.
Related PathwayTransmembrane EndocytosisCell adhesion molecules (CAMs)Antigen processing and presentationNatural killer cell mediated cytotoxicityType I diabetes mellitusAutoimmune thyroid diseaseMore Pathways >>

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

FC Image
Staining of normal human peripheral blood cells with 0.5 ug of Mouse IgG1 K Isotype Control Purified (open histogram) or 0.5 ug of Anti-Human HLA-E Purified (filled histogram) followed by Anti-Mouse IgG Biotin and Streptavidin PE . Cells in the lymphocyte gate were used for analysis.

 

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