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Home Antibody All anti-CBFB antibodies

Anti-CBFB Antibody

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA320210
  • Goat Polyclonal CBFB Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC400665) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
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Also for CBFB (NM_001755)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenPeptide with sequence C-EARRQQDPSPGSN, from the internal region (near C Terminus) of the protein sequence according to NP_074036.1; NP_001746.1
Clone Name IsotypeIgG
Species ReactivityTest: Human. Expected from seq similarity: Human, Mouse, Dog Concentration0.5mg/ml
Guaranteed Application *WB Suggested DilutionsWB: 0.3-1ug/ml, ELISA: 1:2,000
Predicted MW Explanation 22.0kDa
BufferSupplied at 0.5 mg/ml in Tris saline, 0.02% sodium azide, pH7.3 with 0.5% bovine serum albumin
Purification Purified from goat serum by ammonium sulphate precipitation followed by antigen affinity chromatography using the immunizing peptide

Reference Data

Target NameHomo sapiens core-binding factor, beta subunit (CBFB), transcript variant 2
Alternative NamePEBP2B
Database LinkNP_001746
Entrez Gene 865 Human
Entrez Gene 12400 Mouse
Entrez Gene 479690 Dog
FunctionThe protein encoded by this gene is the beta subunit of a heterodimeric core-binding transcription factor belonging to the PEBP2/CBF transcription factor family which master-regulates a host of genes specific to hematopoiesis (e.g., RUNX1) and osteogenesis (e.g., RUNX2). The beta subunit is a non-DNA binding regulatory subunit; it allosterically enhances DNA binding by alpha subunit as the complex binds to the core site of various enhancers and promoters, including murine leukemia virus, polyomavirus enhancer, T-cell receptor enhancers and GM-CSF promoters. Alternative splicing generates two mRNA variants, each encoding a distinct carboxyl terminus. In some cases, a pericentric inversion of chromosome 16 [inv(16)(p13q22)] produces a chimeric transcript consisting of the N terminus of core-binding factor beta in a fusion with the C-terminal portion of the smooth muscle myosin heavy chain 11. This chromosomal rearrangement is associated with acute myeloid leukemia of the M4Eo subtype. Two transcript variants encoding different isoforms have been found for this gene. [provided by RefSeq, Jul 2008].
Related PathwayTranscription FactorsDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Anti-CBFB (0.3ug/ml) staining of Daudi lysate (35ug protein in RIPA buffer). Primary incubation was 1 hour. Detected by chemiluminescence.

 

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