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Anti-TAB3 Antibody Polyclonal
Also for TAB3 (NM_152787)
|TAB3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human TAB3.|
||ELISA, IHC: 5 ug/ml
|TAB3 Antibody is supplied in PBS containing 0.02% sodium azide.|
|TAB3 Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens TGF-beta activated kinase 1/MAP3K7 binding protein 3 (TAB3)|
|TAB3 Antibody: TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.|
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Immunohistochemistry of TAB3 in human kidney tissue with TAB3 antibody at 5 ug/mL.