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Home Antibody All anti-TAB3 antibodies

Anti-TAB3 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA320155
  • Rabbit Polyclonal TAB3 Antibody
100ug $325 3-7 Days
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IHC(1)

OriGene Data

ImmunogenTAB3 antibody was raised against a 13 amino acid synthetic peptide near the amino terminus of human TAB3.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *IHC Suggested DilutionsELISA, IHC: 5 ug/ml
BufferTAB3 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification TAB3 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens TGF-beta activated kinase 1/MAP3K7 binding protein 3 (TAB3)
Alternative NameMAP3K7IP3; NAP1
Database LinkNP_690000
FunctionTAB3 Antibody: TAB3 functions in the NF-kappaB signal transduction pathway. It and the similar and functionally redundant protein TAB2, form a ternary complex with the protein kinase TAK1 and either TRAF2 or TRAF6 in response to stimulation with the pro-inflammatory cytokines TNF or IL-1. Subsequent TAK1 kinase activity triggers a signaling cascade leading to activation of the NF-kappaB transcription factor. Recent experiments have shown that TAB2 and the related protein TAB3 constitutitvely interact with the autophagy mediator Beclin-1; upon induction of autophagy, these proteins dissociate from Beclin-1 and bind TAK1. Overexpression of TAB2 and TAB3 inhibit autophagy, while their depletion triggers it, suggesting that TAB2 and TAB3 act as a control point for autophagy.
Related Pathway

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IHC Image
Immunohistochemistry of TAB3 in human kidney tissue with TAB3 antibody at 5 ug/mL.

 

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