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Anti-NLRP7 Antibody Polyclonal
Also for NLRP7 (NM_206828)
|NALP7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP7.|
||ELISA, WB: 1 ug/ml, IHC: 10 ug/ml, IF: 20 ug/ml
|NALP7 Antibody is supplied in PBS containing 0.02% sodium azide.|
|NALP7 Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens NLR family, pyrin domain containing 7 (NLRP7), transcript variant 2|
|CLR19.4; HYDM; NALP7; NOD12; PAN7; PYPAF3|
|NALP7 Antibody: NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1β secretion and is a feedback regulator of interleukin-1β secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.|
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Western blot analysis of NALP7 in human brain tissue lysate with NALP7 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of NALP7 in human brain tissue with NALP7 antibody at 10 ug/mL.