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Home Antibody All anti-NLRP7 antibodies

Anti-NLRP7 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA320136
  • Rabbit Polyclonal NALP7 Antibody
100ug $325 3-7 Days
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WB(1)
IHC(1)
IF(1)

OriGene Data

ImmunogenNALP7 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human NALP7.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman Concentration1ug/ul
Guaranteed Application *WB, IHC, IF Suggested DilutionsWB: 1 ug/ml, IHC: 10 ug/ml, IF: 20 ug/ml
BufferNALP7 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification NALP7 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens NLR family, pyrin domain containing 7 (NLRP7), transcript variant 2
Alternative NameCLR19.4; HYDM; NALP7; NOD12; PAN7; PYPAF3
Database LinkNP_996611
FunctionNALP7 Antibody: NOD proteins include the apoptosis regulator APAF1 (apoptotic protease activating factor 1) and mammalian NOD-LRR proteins. NALP7, also known as PYPAF3, a member of the related PYRIN-containing APAF1-like proteins (PYPAFs/NALPs) is thought to play a crucial role in cell proliferation. NALP7 has a C-terminal leucine-rich repeat (LRR) region, an N-terminal Pyrin domain (PYD) followed by a NACHT domain, and a NACHT-associated domain. It is expressed in numerous tissues including uterus and ovary, with low levels in heart and brain. NALP7 inhibits caspase-1-dependent interleukin-1β secretion and is a feedback regulator of interleukin-1β secretion. Defects in the NALP7 gene are known to cause the formation of a hydatidiform mole (HYDM) and reduce the growth of carcinoma cell lines.
Related Pathway

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WB Image
Western blot analysis of NALP7 in human brain tissue lysate with NALP7 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
IHC Image
Immunohistochemistry of NALP7 in human brain tissue with NALP7 antibody at 10 ug/mL.
IF Image
Immunofluorescence of NALP7 in human brain tissue with NALP7 antibody at 20 ug/mL.

 

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