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Anti-NLRC3 Antibody Polyclonal
Also for NLRC3 (NM_178844)
|NOD3 antibody was raised against an 18 amino acid synthetic peptide near the center of human NOD3.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IF: 20 ug/ml
|NOD3 Antibody is supplied in PBS containing 0.02% sodium azide.|
|NOD3 Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens NLR family, CARD domain containing 3 (NLRC3), transcript variant 1|
|NOD3 Antibody: NOD3 is a member of the NOD (nucleotide-binding oligomerization domain) family, a group of proteins that are involved in innate immune defense. NOD3 also known as NLR family CARD containing 3 (NLRC3), is predominantly expressed in the immune system, particularly in T lymphocytes, and its expression is strongly down-regulated following stimulation of the T-cell receptor complex and CD28, suggesting that NOD3 plays a role in attenuating the activation of T cells. NOD3 inhibits NF-kappaB, AP-1 and NFAT transcriptional activation in Jurkat T cells downstream of CD3/CD28 stimulation or treatment with PMA/ionomycin and decreases IL-2 and CD25 mRNA induction in activated cells.|
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Western blot analysis of NOD3 in 3T3 cell lysate with NOD3 antibody at (A) 1 and (B) 2 ug/mL.
Immunofluorescence of NOD3 in Jurkat cells with NOD3 antibody at 20 ug/mL.