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Home Antibody All anti-MSI2 antibodies

Anti-MSI2 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA320090
  • Rabbit Polyclonal MSI2 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC403371) , 20ug Explanation
100ug 325 3-7 Days
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WB(1)
IF(1)
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Also for MSI2 (NM_138962)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenMSI2 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human MSI2.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 ug/ml, ICC: 5 ug/ml, IF: 5 ug/ml
BufferMSI2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification MSI2 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens musashi RNA-binding protein 2 (MSI2), transcript variant 1
Alternative NameMSI2H
Database LinkNP_620412
Entrez Gene 124540 Human
Entrez Gene 76626 Mouse
Entrez Gene 360596 Rat
FunctionMSI2 Antibody: Musashi2 (MSI2) is an RNA-binding protein that is highly expressed in precursor cells in the ventricular and subventricular zones of the developing mammalian CNS. Like the related MSI1, MSI2 has been suggested to be involved stem cell production and maintenance. MSI2 is the predominant MSI protein in hematopoietic stem cells, and its knockdown leads to reduced engraftment and depletion in vivo. Expression levels of MSI2 are elevated in myeloid leukemia cells lines, and MSI2 appears to cooperate with BCR-ABL1 to induce an aggressive leukemia; the level of MSI2 directly correlates with decreased survival in patients. MSI2 negatively regulates the asymmetric cell fate determinant NUMB, suggesting that this signaling pathway may provide future targets for future therapies.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of MSI2 in EL4 cell lysate with MSI2 antibody at 1 ug/mL.
IF Image
Immunofluorescence of MSI2 in EL4 cells with MSI2 antibody at 20 ug/mL.

 

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