Home Antibody All anti-ALKBH2 antibodies
Anti-ALKBH2 Antibody Polyclonal
Also for ALKBH2 (NM_001001655)
|ALKBH2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ALKBH2.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IHC: 10 ug/ml
|ALKBH2 Antibody is supplied in PBS containing 0.02% sodium azide.|
|ALKBH2 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens alkB, alkylation repair homolog 2 (E. coli) (ALKBH2), transcript variant 2|
Entrez Gene 121642 Human
Entrez Gene 231642 Mouse
Entrez Gene 304578 Rat
|ALKBH2 Antibody: The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA; ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that left unchecked could lead to cancerous cells. Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer. Conversely, ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy, an adjuvant therapy in cancer treatment, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.|
|Druggable Genome |
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Western blot analysis of ALKBH2 in human kidney tissue lysate with ALKBH2 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of ALKBH2 in human kidney tissue with ALKBH2 antibody at 10 ug/mL.