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Home Antibody All anti-ALKBH2 antibodies

Anti-ALKBH2 Antibody Polyclonal

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Specifications Citations (0) Related Products Product Documents
SKU Description Amount Price Availability*  
TA320088 Rabbit Polyclonal ALKBH2 Antibody 100ug $325 3-7 Days
LC400362 ALKBH2 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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WB(1)
IHC(1)
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Also for ALKBH2 (NM_001001655)
cDNA Clone shRNA/siRNA CRISPR KO Kit Protein Antibody

OriGene Data

ImmunogenALKBH2 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ALKBH2.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 1 - 2 ug/ml, IHC: 10 ug/ml
BufferALKBH2 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification ALKBH2 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens alkB, alkylation repair homolog 2 (E. coli) (ALKBH2), transcript variant 2
Alternative NameABH2
Database LinkNP_001001655
Entrez Gene 121642 Human
Entrez Gene 231642 Mouse
Entrez Gene 304578 Rat
FunctionALKBH2 Antibody: The E. coli AlkB protein protects against the cytotoxicity of methylating agents by repair of the specific DNA lesions generated in single-stranded DNA; ALKBH2 and ALKBH3 are mammalian homologs of AlkB that catalyze the removal of 1-methyladenine and 3-methylcytosine, modifications that left unchecked could lead to cancerous cells. Mutations in both ALKBH2 and ALKBH3 have been observed in pediatric brain tumors indicating that these proteins are important in the prevention of cancer formation. Like the histone demethylase JMJD1A, ALKBH2 is a non-heme iron enzyme that is inhibited by Nickel ions, suggesting that inhibition of ALKBH2 by Nickel ions may play a role in the development of cancer. Conversely, ALKBH2 mRNA and protein levels are increased glioma cells following Photofrin-mediated photodynamic therapy, an adjuvant therapy in cancer treatment, suggesting that down-regulating ALKBH2 expression in cancer cells may enhance the anti-cancer effectiveness of this treatment.
Related PathwayDruggable Genome

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of ALKBH2 in human kidney tissue lysate with ALKBH2 antibody at (A) 1 and (B) 2 ug/mL.
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Immunohistochemistry of ALKBH2 in human kidney tissue with ALKBH2 antibody at 10 ug/mL.
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