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Home Antibody All anti-TCTN1 antibodies

Anti-TCTN1 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA320013
  • Rabbit Polyclonal TCTN1 Antibody
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for TCTN1 (NM_001082537)
cDNA Clone shRNA/siRNA Lysate Protein Antibody

OriGene Data

ImmunogenTCTN1 antibody was raised against a 15 amino acid synthetic peptide near the amino terminus of human TCTN1.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
BufferTCTN1 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification TCTN1 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens tectonic family member 1 (TCTN1), transcript variant 2
Alternative NameJBTS13; TECT1
Database LinkNP_001076006
FunctionTCTN1 Antibody: TCTN1 is the founding member of the Tectonic protein family, a group of evolutionarily conserved secreted and transmembrane proteins that regulate the Hedgehog (Hh)-mediated patterning of the neural tube. During embryonic development, TCTN1 is expressed in regions that participate in Hh signaling, beginning in the gastrulation stages in the ventral node. Mice expressing mutant TCTN1 die between E13.5 and E16.5 and display holoprosencephaly, a defect associated with reduced Hh signaling, indicating the role of TCTN1 as an Hh activator. At later stages in development, TCTN1 is thought to also act as a repressor on the Hh pathway in the anterior and posterior neural tube.
Related Pathway

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WB Image
Western blot analysis of TCTN1 in mouse kidney tissue lysate with TCTN1 antibody at (A) 1 and (B) 2ug/mL.
IHC Image
Immunohistochemistry of TCTN1 in human kidney tissue with TCTN1 antibody at 5 ug/mL.

 

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