Home Antibody All anti-ANAPC5 antibodies
Anti-ANAPC5 Antibody Polyclonal
Also for ANAPC5 (NM_016237)
|APC5 antibody was raised against a 17 amino acid synthetic peptide near the center of human APC5.|
|Human, Mouse, Rat
|WB, IHC, IF
||WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|APC5 Antibody is supplied in PBS containing 0.02% sodium azide.|
|APC5 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens anaphase promoting complex subunit 5 (ANAPC5), transcript variant 1|
Entrez Gene 51433 Human
Entrez Gene 59008 Mouse
Entrez Gene 288671 Rat
|APC5 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC5 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC5, it is thought that APC5 associates with other APC/C components APC1, APC4, and CDC23 interdependently, such that loss of any one subunit reduces binding between the remaining three.|
|Druggable Genome Cell cycleOocyte meiosisUbiquitin mediated proteolysisProgesterone-mediated oocyte maturation|
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Western blot analysis of APC5 in human kidney tissue lysate with APC5 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of APC5 in rat kidney tissue with APC5 antibody at 5 ug/mL.
Immunofluorescence of APC5 in rat kidney tissue with APC5 antibody at 20 ug/mL.