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Anti-WAC Antibody Polyclonal
|WAC antibody was raised against a 19 amino acid peptide near the center of human WAC .|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, IHC, IF
|Predicted: 71 kDa Observed: 75 kDa
|WAC Antibody is supplied in PBS containing 0.02% sodium azide.|
|WAC Antibody is affinity chromatography purified via peptide column.
|Homo sapiens WW domain containing adaptor with coiled-coil (WAC), transcript variant 1|
|BM-016; PRO1741; Wwp4|
Entrez Gene 51322 Human
Entrez Gene 225131 Mouse
Entrez Gene 307029 Rat
|WAC Antibody: The WW domain containing adaptor with coiled-coil protein (WAC) contains a WW domain that mediates protein-protein interactions and colocalizes with RNA splicing factor SC35. Further studies have indicated that WAC is a functional partner of the RNF20/40 complex that ubiquitinates Histone H2B, and that WAC regulates H2B ubiquitination. WAC targets RNF20/40 to associate with RNA polymerase II complex for H2B ubiquitination at active transcription sites. WAC-dependent transcription is also important for cell-cycle checkpoint activation in response to genotoxic stress.|
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Western blot analysis of WAC in human testis tissue lysate with WAC antibody at 1 ug/mL.