Home Antibody All anti-TMEM59L antibodies
Anti-TMEM59L Antibody Polyclonal
Also for TMEM59L (NM_012109)
|TMEM59L antibody was raised against a 19 amino acid synthetic peptide near carboxy terminus of human TMEM59L.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, IHC: 2.5 ug/ml, IF: 20 ug/ml
|TMEM59L Antibody is supplied in PBS containing 0.02% sodium azide.|
|TMEM59L Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens transmembrane protein 59-like (TMEM59L)|
|TMEM59L Antibody: Processing of the amyloid precursor protein (APP) by two different proteases, called alpha- and beta-secretase, is a central regulatory event in the generation of the amyloid beta peptide (Abeta), which has a key role in Alzheimer disease (AD) pathogenesis. TMEM59L is a type I membrane glycoprotein that is expressed in the brain. A related protein, TMEM59, is a Golgi-localized protein that modulates the O-glycosylation and complex N-glycosylation steps occurring during the Golgi maturation of several proteins such as APP, BACE1, SEAP or PRNP and inhibits APP transport and shedding.|
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Western blot analysis of TMEM59L in rat heart tissue lysate with TMEM59L antibody at 1 ug/mL.
Immunohistochemistry of TMEM59L in mouse brain tissue with TMEM59L antibody at 2.5 ug/mL.