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Home Antibody All anti-KDM6B antibodies

Anti-KDM6B Antibody Polyclonal

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SKU Description Amount Price Availability*  
TA319844
  • Rabbit Polyclonal JMJD3 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC421641) , 20ug Explanation
100ug $325 In Stock
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WB(1)
IF(1)

OriGene Data

ImmunogenJMJD3 antibody was raised against a 16 amino acid synthetic peptide from near the amino terminus of human JMJD3.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 0.5 ug/ml, ICC: 2.5 ug/ml, IF: 5 ug/ml
BufferJMJD3 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification JMJD3 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens lysine (K)-specific demethylase 6B (KDM6B)
Alternative NameJMJD3
Database LinkNP_001073893
Entrez Gene 23135 Human
Entrez Gene 216850 Mouse
Entrez Gene 363630 Rat
FunctionJMJD3 Antibody: The Jumonji domain-containing protein 3 (JMJD3) functions as a trimethylation-specific demethylase, converting the trimethylated histone H3 Lys27 residue to the dimethylated form, and is thought to also function as a transcriptional repressor. JMJD3 plays a central role in regulation of posterior development, by regulating HOX gene expression. It is involved in inflammatory response by participating in macrophage differentiation in case of inflammation by regulating gene expression and macrophage differentiation. JMJD3 can also interact with and demethylate p53, resulting in its stabilization and localization to the nucleus in mouse embryo fibroblasts during neural stem cell differentiation.
Related Pathway

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

Western blot analysis of JMJD3 in K562 cell lysate with JMJD3 antibody at 0.5 ug/mL in (A) the absence and (B) the presence of blocking peptide.
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Immunofluorescence of JMJD3 in K562 cells with JMJD3 antibody at 20 ug/mL.
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