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Home Antibody All anti-ATG13 antibodies

Anti-ATG13 Antibody Polyclonal

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Specifications Citations Related Products Product Documents
SKU Description Amount Price Availability*  
TA319788
  • Rabbit Polyclonal ATG13 Antibody
  • Free Sample of Positive Control: HEK293T cell transient overexpression lysate (LC428237) , 20ug
100ug 325 3-7 Days
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WB(1)
IHC(1)
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Also for ATG13 (NM_001142673)
cDNA Clone shRNA/siRNA Lysate Protein Request Antibody

OriGene Data

ImmunogenATG13 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human ATG13.
Clone NamePolyclonal IsotypeIgG
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IHC Suggested DilutionsELISA, WB: 1 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
BufferATG13 Antibody is supplied in PBS containing 0.02% sodium azide.
Purification ATG13 Antibody is affinity chromatography purified via peptide column.

Reference Data

Target NameHomo sapiens autophagy related 13 (ATG13), transcript variant 1
Alternative NameKIAA0652; PARATARG8
Database LinkNP_001136145
FunctionATG13 Antibody: Autophagy, the process of bulk degradation of cellular proteins through an autophagosomic-lysosomal pathway is important for normal growth control and may be defective in tumor cells. It is involved in the preservation of cellular nutrients under starvation conditions as well as the normal turnover of cytosolic components. This process is negatively regulated by TOR (Target of rapamycin) through phosphorylation of autophagy protein ATG1. ATG13 forms a complex with ULK1 and ULK2, the mammalian homologs of ATG1, and with FIP200. This complex is a target of TOR phosphorylation under normal conditions; inhibition of TOR by rapamycin or leucine deprivation leads to dephosphorylation of ATG13, ULK1 and ULK2, which then leads to autophagy. Knockdown of ATG13 inhibits autophagosome formation.
Related Pathway

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* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of ATG13 in rat heart tissue lysate with ATG13 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
IHC Image
Immunohistochemistry of ATG13 in mouse heart with ATG13 antibody at 5 ug/mL.

 

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