Home Antibody All anti-EI24 antibodies
Anti-EI24 Antibody Polyclonal
Also for EI24 (NM_004879)
|EI24 antibody was raised against a 19 amino acid synthetic peptide near the carboxy terminus of human EI24.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IHC: 5 ug/ml
|EI24 Antibody is supplied in PBS containing 0.02% sodium azide.|
|EI24 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens etoposide induced 2.4 (EI24), transcript variant 1|
|EPG4; PIG8; TP53I8|
Entrez Gene 9538 Human
Entrez Gene 13663 Mouse
Entrez Gene 300514 Rat
|EI24 Antibody: The etoposide-induced 24 (EI24) protein is an immediate-early induction target of p53-mediated apoptosis and functions as a tumor suppressor. EI24 contains six transmembrane domains and is localized to the endoplasmic reticulum (ER). It binds to Bcl-2 and may contribute to apoptosis by modulating the activity and function of Bcl-2. EI24 is highly mutated in aggressive breast cancers and its loss in breast cancer tissue correlates with tumor invasiveness. Similar findings in invasive cervical carcinoma suggest that EI24 may be a promising therapeutic target in the treatment of invasive cancer. |
|TransmembraneDruggable Genome p53 signaling pathway|
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Western blot analysis of EI24 in rat liver tissue lysate with EI24 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of EI24 in rat liver tissue with EI24 antibody at 5 ug/mL.