Home Antibody All anti-CDC16 antibodies
Anti-CDC16 Antibody Polyclonal
Also for CDC16 (NM_001078645)
|APC6 antibody was raised against an 18 amino acid synthetic peptide near the amino terminus of human APC6.|
|WB, IHC, IF
||WB: 1 - 2 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|APC6 Antibody is supplied in PBS containing 0.02% sodium azide.|
|APC6 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens cell division cycle 16 (CDC16), transcript variant 2|
|ANAPC6; APC6; CUT9|
Entrez Gene 8881 Human
Entrez Gene 69957 Mouse
|APC6 Antibody: Cell cycle regulated protein ubiquitination and degradation within subcellular domains is thought to be essential for the normal progression of mitosis. APC6 is a highly conserved component of the anaphase promoting complex/cyclosome (APC/C), a cell cycle-regulated E3 ubiquitin ligase that controls progression through mitosis and the G1 phase of the cell cycle. APC/C is responsible for degrading anaphase inhibitors, mitotic cyclins, and spindle-associated proteins ensuring that events of mitosis take place in proper sequence. The individual APC/C components mRNA and protein levels are expressed at approximately the same levels in most tissues and cell lines, suggesting that they perform their functions as part of a complex. While little is known of APC6, it has been shown to interact with and is stabilized by CDC26 through an intermolecular TPR mimic composed of one helix from each protein.|
|Druggable Genome Cell cycleOocyte meiosisUbiquitin mediated proteolysisProgesterone-mediated oocyte maturation|
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Western blot analysis of APC6 in human liver tissue lysate with APC6 antibody at (A) 1 and (B) 2 ug/mL.
Immunohistochemistry of APC6 in human liver tissue with APC6 antibody at 5 ug/mL.
Immunofluorescence of APC6 in human liver tissue with APC6 antibody at 20 ug/mL.