Home Antibody All anti-PIAS1 antibodies
Anti-PIAS1 Antibody Polyclonal
Also for PIAS1 (NM_016166)
|PIAS1 antibody was raised against a 15 amino acid synthetic peptide near the carboxy terminus of human PIAS1.|
|Human, Mouse, Rat
|WB, IHC, IF
||WB: 1 ug/ml, IHC: 5 ug/ml, IF: 20 ug/ml
|PIAS1 Antibody is supplied in PBS containing 0.02% sodium azide.|
|PIAS1 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens protein inhibitor of activated STAT, 1 (PIAS1)|
|DDXBP1; GBP; GU/RH-II; ZMIZ3|
Entrez Gene 8554 Human
Entrez Gene 56469 Mouse
Entrez Gene 300772 Rat
|PIAS1 Antibody: The PIAS proteins (protein inhibitor of activated STAT) play a crucial role as transcriptional coregulators in various cellular pathways, including the STAT, p53 and the steroid hormone signaling pathway. The PIAS protein family includes at least five evolutionarily conserved genes, including PIAS1. The major function of the PIAS proteins is the control of gene transcription and can also act as small ubiquitin-like-modifier (SUMO) E3 ligases. PIAS1 binds specifically to STAT1, inhibiting STAT1-mediated gene activation and also binds to the Gu/RNA helicase II enzyme, leading to the proteolytic cleavage of Gu/RH-II. PIAS1 is a potent co-activator for CP2c-mediated alpha-globin expression in erythroid cells.|
|Transcription FactorsDruggable Genome Ubiquitin mediated proteolysisJak-STAT signaling pathwayPathways in cancerSmall cell lung cancer|
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* OriGene provides validated application data and protocol, with money back guarantee.
Western blot analysis of PIAS1 in human kidney tissue lysate with PIAS1 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunohistochemistry of PIAS1 in rat kidney tissue with PIAS1 antibody at 5 ug/mL.
Immunofluorescence of PIAS1 in rat kidney tissue with PIAS1 antibody at 20 ug/mL.