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Anti-AXIN1 Antibody Polyclonal
Also for AXIN1 (NM_003502)
|AXIN1 antibody was raised against a 14 amino acid synthetic peptide near the carboxy terminus of human AXIN1.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml, IF: 20 ug/ml
|AXIN1 Antibody is supplied in PBS containing 0.02% sodium azide.|
|AXIN1 Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens axin 1 (AXIN1), transcript variant 1|
|AXIN1 Antibody: AXIN1 is a cytoplasmic protein which contains a regulation of G-protein signaling (RGS) domain and a dishevelled and axin (DIX) domain and is thought to function as a negative regulator of the WNT signaling pathway that regulates embryonic axis formation. AXIN1 interacts with adenomatosis polyposis coli (APC), beta-catenin, glycogen synthase kinase 3 beta, forming a tetrameric complex resulting in the regulation of the stabilization of beta-catenin. Mutations in the AXIN1 gene have been associated various carcinomas, indicating that it also functions as a tumor suppressor. |
TGF Beta Signaling Pathway
Wnt Signaling Pathway
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Western blot analysis of AXIN1 in SK-N-SH cell lysate with AXIN1 antibody at 1 ug/mL.
Immunofluorescence of AXIN1 in human brain tissue with AXIN1 antibody at 20 ug/mL.