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Anti-XBP1 Antibody 3H1G4
Also for XBP1 (NM_001079539)
|Mouse monoclonal XBP-1 antibody was raised against recombinant protein corresponding to amino acids 2 to 160 of human XBP-1.|
|Human, Mouse, Rat
||ELISA, WB: 1 ug/ml, ICC: 2 ug/ml, IF: 4 ug/ml
|XBP-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.|
|XBP-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.
|Homo sapiens X-box binding protein 1 (XBP1), transcript variant 2|
|TREB-5; TREB5; XBP-1; XBP2|
Entrez Gene 7494 Human
Entrez Gene 22433 Mouse
Entrez Gene 289754 Rat
|XBP-1 Monoclonal Antibody: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.|
|Transcription Factors |
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Western blot analysis of 100 ng of XBP-1 recombinant protein with XBP-1 antibody at 1 ug/mL.
Immunocytochemistry of XBP-1 in HepG2 cells with XBP-1 antibody at 2 ug/mL.