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Home Antibody All anti-XBP1 antibodies

Anti-XBP1 Antibody 3H1G4


Specifications Citations Customer Reviews Product Documents
SKU Description Amount Price Availability*  
TA319736 Mouse XBP-1 Monoclonal Antibody 100ug $325 3-7 Days
LC401569 XBP1 HEK293T cell transient overexpression lysate (as WB positive control) 20ug $50 In Stock
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OriGene Data

ImmunogenMouse monoclonal XBP-1 antibody was raised against recombinant protein corresponding to amino acids 2 to 160 of human XBP-1.
Clone Name3H1G4 IsotypeIgG1
Species ReactivityHuman, Mouse, Rat Concentration1ug/ul
Guaranteed Application *WB, IF Suggested DilutionsWB: 1 ug/mL, ICC: 2 ug/mL, IF: 4 ug/mL
BufferXBP-1 Monoclonal Antibody is supplied in PBS containing 0.02% sodium azide.
Purification XBP-1 Monoclonal Antibody is immunoaffinity chromotography purified IgG.

Reference Data

Target NameX-box binding protein 1
Alternative NameTREB-5|TREB5|XBP-1|XBP2
Database LinkNP_001073007
Entrez Gene 7494 Human
Entrez Gene 22433 Mouse
Entrez Gene 289754 Rat
FunctionXBP-1 Monoclonal Antibody: X box binding protein 1 (XBP-1) is a key protein in the mammalian unfolded protein response (UPR) that protects the cell against the stress of malfolded proteins in the endoplasmic reticulum (ER). Upon sensing unfolded proteins, an ER transmembrane endonuclease and kinase termed IRE1p is activated and excises an intron from XBP-1 mRNA. The spliced XBP-1 mRNA results in a 371 amino acid protein (XBP-1s) which is then translocated to the nucleus where it binds to the regulatory elements of downstream genes. Together with other UPR transcription factors such as ATF6, XBP-1 stimulates the production of ER stress proteins including the ER resident protein chaperones glucose regulated protein (GRP) 78 and GRP94.
Related PathwayTranscription Factors

* Availability is in business days
* OriGene provides validated application data and protocol, with money back guarantee.

WB Image
Western blot analysis of 100 ng of XBP-1 recombinant protein with XBP-1 antibody at 1 ug/mL.

IF Image
Immunocytochemistry of XBP-1 in HepG2 cells with XBP-1 antibody at 2 ug/mL.

IF Image
Immunofluorescence of XBP1 in HepG2 cells with XBP1 antibody at 4 ug/mL.


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