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Anti-IRF4 Antibody Polyclonal
Also for IRF4 (NM_001195286)
|IRF4 antibody was raised against a 16 amino acid synthetic peptide near the carboxy terminus of human IRF4.|
|Human, Mouse, Rat
||WB: 1 ug/ml, ICC: 10 ug/ml, IF: 20 ug/ml
|IRF4 Antibody is supplied in PBS containing 0.02% sodium azide.|
|IRF4 Antibody is affinity chromatography purified via peptide column.
|Homo sapiens interferon regulatory factor 4 (IRF4), transcript variant 2|
|LSIRF; MUM1; NF-EM5|
|IRF4 Antibody: Interferons (IFNs) are involved in a multitude of immune interactions during viral infections and play a major role in both the induction and regulation of innate and adaptive antiviral mechanisms. During infection, host-virus interactions signal downstream molecules such as transcription factors such as IFN regulatory factor-3 (IRF3) which can act to stimulate transcription of IFN-alpha/beta genes. Another member, IRF7 has been shown to play a role in the transcriptional activation of virus-inducible cellular genes, including interferon beta chain genes. IRF4 expression is tightly regulated in resting primary T cells and plays an essential role in the homeostasis and function of mature lymphocytes. IRF4 is induced by Toll-like receptor (TLR) activation and acts as a negative regulator of TLR signaling.|
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Western blot analysis of IRF4 in Jurkat cell lysate with IRF4 antibody at 1 ug/mL in (A) the absence and (B) the presence of blocking peptide.
Immunofluorescence of IRF4 in Jurkat cells with IRF4 antibody at 20 ug/mL.