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Anti-IDH1 Antibody Polyclonal
Also for IDH1 (NM_005896)
|IDH1 antibody was raised against a 13 amino acid synthetic peptide near the carboxy terminus of human IDH1.|
|Human, Mouse, Rat
||ELISA, WB: 1 - 2 ug/ml
|IDH1 Antibody is supplied in PBS containing 0.02% sodium azide.|
|IDH1 Antibody is affinity chromatography purified via peptide column. (Protein A or G Sepharose)
|Homo sapiens isocitrate dehydrogenase 1 (NADP+), soluble (IDH1), transcript variant 1|
|IDCD; IDH; IDP; IDPC; PICD|
|IDH1 Antibody: Isocitrate dehydrogenases catalyze the oxidative decarboxylation of isocitrate to 2-oxoglutarate. These enzymes belong to two distinct subclasses, one of which utilizes NAD(+) as the electron acceptor and the other NADP(+). Two NADP(+)-dependent isocitrate dehydrogenases have been found as homodimer: IDH1 is predominantly cytosolic and peroxisomal and IDH2 is mitochondrial. The presence of IDH1 in peroxisomes suggests it may play a role in the regeneration of NADPH for intraperoxisomal reductions, such as the conversion of 2, 4-dienoyl-CoAs to 3-enoyl-CoAs, as well as in peroxisomal reactions that consume 2-oxoglutarate, namely the alpha-hydroxylation of phytanic acid. The cytoplasmic IDH1 serves a significant role in cytoplasmic NADPH production. Defects in IDH1 are involved in the development of glioma. |
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Western blot analysis of IDH1 in HepG2 cell lysate with IDH1 antibody at (A) 1 and (B) 2 ug/mL.